CONGENITAL HEART DISEASE

This study follows children with congenital heart disease who have had the Fontan procedure and are prescribed rivaroxaban, a blood thinner, to prevent dangerous clots. Researchers will track bleeding events and other side effects using data from regular doctor visits. The goal i…

This study looks at how well the Medtronic Harmony Transcatheter Pulmonary Valve (TPV) works when used by doctors in everyday practice. It involves 150 people with certain heart defects who need a new pulmonary valve. The main goal is to see if the valve works properly and safely…

This study looks at a new valve called the Harmony TPV that can be placed inside the heart using a thin tube through a blood vessel, avoiding open-heart surgery. It is for people with certain types of congenital heart disease who have a leaky valve. The goal is to see if the valv…

This study tests a new device combination (Alterra Prestent and SAPIEN 3 valve) to repair a leaky pulmonary heart valve in people born with heart defects. About 86 participants with moderate or severe leakage will get the device through a tube in a blood vessel, avoiding open-hea…

This study tests whether adding nitric oxide to the heart-lung machine during surgery can reduce brain and kidney damage in infants with congenital heart disease. Researchers will measure specific proteins in the blood before and after surgery and monitor for confusion and kidney…

This study tests a special heart valve for children aged 1.5 to 16 years with congenital heart disease who need a new pulmonary valve. The valve can be expanded after surgery as the child grows, potentially reducing the need for repeat operations. Researchers will check safety an…

This study is testing a new driving system for the Berlin Heart EXCOR, a heart pump used in children with severe heart failure who are waiting for a heart transplant. The goal is to see if the new system works safely and effectively. About 40 children will take part, and the stud…

This study looks at whether the drug propranolol can safely and quickly treat a serious fluid buildup called chylothorax that can happen after open-heart surgery in children with congenital heart disease. About 50 children aged 7 days to 18 years will be randomly assigned to rece…

This study tests whether special low-energy MRI settings can make it safe to use standard guidewires during heart catheterization. Guidewires help doctors position catheters in the heart, but they usually pose a heating risk in MRI machines. The goal is to see if this approach ca…

This study was designed to find out if blood tests taken during and after pregnancy in women with adult congenital heart disease could help predict future heart problems like arrhythmias or heart failure. It planned to enroll pregnant women with congenital heart disease, but the …

This study looks at 224 adults who had heart surgery for tetralogy of Fallot as children. Researchers want to see if heart scarring, measured by MRI and blood tests, is linked to future heart problems like arrhythmias or heart failure. The goal is to better understand which patie…

This study looks at proteins in the blood of 60 children with congenital heart disease after heart surgery. The goal is to find which proteins can predict serious complications like fluid overload or organ injury. By combining protein data with patient information, researchers ho…

This study looks at whether a web-based decision aid can reduce stress for parents whose baby is diagnosed with a life-threatening heart condition before or shortly after birth. About 135 parents will be randomly assigned to use the decision aid alone or with an extra values-clar…