Charite University, Berlin, Germany

This study tests whether newer, targeted immunotherapy drugs (inotuzumab and blinatumomab) can replace toxic chemotherapy for children whose B-cell acute lymphoblastic leukemia has returned. About 750 children and teens up to age 21 will be enrolled across multiple countries. The…

This study looks at whether a special breathing technique (lung volume optimization maneuver) can improve heart and lung function in 80 children having heart surgery. The approach involves adjusting ventilator settings to find the best lung volume. Researchers will measure blood …

This study looks at how artificial sweeteners (saccharin, sucralose) and a natural one (erythritol) affect blood sugar control, blood clotting, and heart disease risk in 80 adults with prediabetes. Participants will be assigned to one of four groups and consume a sweetener or wat…

This study will follow about 12,750 adults and children who have had a stroke (either from a clot or bleeding in the brain). Researchers will collect information from before hospital arrival through recovery and long-term follow-up to understand what treatments work best and how …

Many gynecologists overestimate the benefits of ovarian cancer screening for average-risk women. This study will test whether a short AI-guided conversation can correct these misperceptions. About 350 gynecologists will participate, comparing an AI discussion about screening evid…