Can a vacuum device safely suck out dangerous heart clots? a global registry investigates
NCT ID NCT07769320
First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time
Summary
This study is a large international registry that will look back at the medical records of about 1,000 adults who were treated with the AngioVac system, a device that uses suction to remove blood clots, infected tissue, or other unwanted material from the heart and major blood vessels. The goal is to understand how safe and effective the device is in everyday clinical practice across a wide range of conditions, including heart infections and clots in the heart or lungs. By analyzing outcomes and complications, researchers hope to identify which patients benefit most and to develop best-practice recommendations for its use.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- AngioVac aspiration system (a device used to suction out unwanted material from blood vessels and heart chambers)
- What this could lead to
- If successful, this study could provide clearer guidance on when and how to use the AngioVac device, potentially improving outcomes for people with dangerous blood clots or heart infections.
- What could go wrong
- This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may be limited by incomplete data or differences in how centers use the device.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 1,000 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
All patients who underwent an AngioVac procedure during the specified and mentioned time period.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥18 years at time of AngioVac procedure 2. Patient underwent percutaneous AngioVac aspiration (any AngioVac model or version used clinically during study period) 3. Procedure performed within study period (January 2018 (or site's institutional start date) - June 2026) 4. Written informed consent OR documented waiver/exemption from ethics authority (per local regulations per GDPR) Exclusion Criteria: 1. Insufficient documentation to assess primary safety or effectiveness endpoints (e.g. defined as \>20% missing data in core endpoint variables) 2. Patient objection to retrospective data use (where required by local law; GDPR Article 21 opt-out; honored without study impact) 3. Non-AngioVac procedures: Patients undergoing thrombus/vegetation removal by surgery or other percutaneous devices only (not AngioVac)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Charité - Universitätsmedizin Berlin, Deutsches Herzzentrum der Charité, Department of Cardiothoracic and Vascular Surgery
Berlin, 13353, Germany
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