Virus cocktail fights deadly heart infection in new trial
NCT ID NCT06870409
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding a special virus mixture (phage therapy) to standard antibiotics can improve outcomes for people with a serious heart valve infection called infective endocarditis. About 30 participants will receive either the phage therapy or a placebo alongside their usual antibiotics. The goal is to see if the combination reduces hospital stays, blood clots, and deaths.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2025
- Expected to finish
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Feb 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Hospitalisation with active IE or active IE developed in hospital; * Definite diagnosis of IE according to modified Duke 2023 criteria or possible diagnosis of IE but managed and treated as IE; * Informed consent to participate in the study; Exclusion Criteria: * Inactive (transferred) IE * Non-bacterial thrombotic endocarditis * Active oncological diseases * Immunosuppressive therapy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University Clinical Hospital named after V.V.Vinogradov (branch) of the Peoples' Friendship University of Russia named after Patrice Lumumba
RECRUITINGMoscow, Russia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Folate tracer lights up inflamed hearts in PET scan study
- Could a donor heart valve beat Man-Made ones for treating severe valve infections?
- Can a vacuum device safely suck out dangerous heart clots? a global registry investigates
- Could a simple dental cleaning prevent a deadly heart infection?
- Heart infection registry aims to unlock better treatments
- One or two infusions could replace weeks of antibiotics for heart infection