Charite University, Berlin, Germany

This study is testing a new type of heart valve made from the patient's own tissue for people with a leaky pulmonary valve. The valve is designed to grow with the patient, potentially reducing the need for repeat surgeries. The trial will enroll 7 adults to check if the valve is …

This study tests whether adding the drug bortezomib to standard chemotherapy helps children and teens with high-risk relapsed acute lymphoblastic leukemia (ALL) achieve remission and live longer. About 250 participants under 18 will be randomly assigned to receive either standard…

This study tests a method called normothermic machine perfusion, which keeps donated livers working outside the body so doctors can check their quality. The goal is to safely use livers that were previously considered unsuitable, helping 186 adults on the transplant waiting list …

This study tests a 12-week, sensor-guided exercise program for people who recently had ACL knee surgery. The program aims to correct how the knee moves during walking, which may reduce joint inflammation and prevent the development of knee osteoarthritis. Researchers will enroll …

This study compares two ways to find psoriatic arthritis (PsA) in people with psoriasis: a questionnaire filled out by the patient versus a physical exam by a dermatologist. About 500 adults with psoriasis will be checked using both methods, then referred to a rheumatologist for …

This study tests a care program to prevent delirium (sudden confusion) in older patients after surgery. It involves over 18,000 people aged 70 and older. The program uses regular checks and early treatment to reduce risk and improve recovery.

This study looks at whether heart attack survivors with weak hearts can do just as well with modern medications alone compared to getting a defibrillator implant. About 3,600 participants who have had a heart attack and have a weak heart pump will be randomly assigned to either g…

This study tests two acupuncture methods—one with mild electrical pulses and one with simple touch—to see which better helps bladder control in women with multiple sclerosis. About 150 women aged 18-60 with MS and bladder issues will be randomly assigned to one of the two treatme…

This study tests whether a gentle nerve stimulation technique (tVNS) can make mindfulness training more effective at preventing relapse in people recovering from alcohol dependence. 140 detoxified patients will practice mindfulness with or without the stimulation. Researchers wil…

This study tests whether giving oxytocin (a natural hormone) as a nasal spray before mindfulness group therapy can improve negative symptoms like lack of motivation and social withdrawal in people with schizophrenia. About 120 adults with schizophrenia will receive either a low o…

This study is testing a blood-filtering procedure called immunoadsorption (IA) in 50 adults with ME/CFS or Long COVID who have specific autoantibodies. The goal is to see if removing these antibodies can ease symptoms like severe fatigue and improve daily function. Participants w…

This study tests whether a special lighting program can help restore normal day-night rhythms in ICU patients who are confused or delirious. Forty adults in the ICU will receive either the dynamic light therapy or standard hospital lighting. Researchers will measure changes in me…

This study tests whether a yoga-based group program can help outpatients with schizophrenia spectrum disorders feel better. About 60 adults will be randomly assigned to yoga plus usual care, strength training plus usual care, or usual care alone. Researchers will measure stress, …

This study tests whether a smartphone app called Kiso Mind is acceptable and practical for people with schizophrenia or schizoaffective disorder. About 60 participants will either use the app plus their usual care, or just usual care, for 12 weeks. The main goal is to see if peop…

This study aims to reduce suffering for adults in the intensive care unit (ICU) by having palliative care specialists consult on their care. Researchers will track how long patients stay in the ICU and whether the consultations help them leave sooner. The study involves about 2,0…

This study is testing a self-guided internet program called Velibra for people with anxiety disorders who are on a waitlist for treatment. The program uses cognitive behavioral therapy techniques to help reduce symptoms. About 30 adults with panic disorder, social anxiety, or gen…

This study tests whether a personalized lung inflation technique can improve heart and lung function in two groups of children on breathing machines: those recovering from heart surgery and those with severe respiratory failure. Researchers will measure how well the lungs and hea…

This study reviews data from 5,000 adults who had surgery to find out how often thinking problems (like memory loss or confusion) occur after an operation. Researchers will look at test results from before and after surgery to estimate how common these issues are. No new treatmen…

This study looks at how well CFTR modulator drugs work in people with cystic fibrosis. Researchers will measure changes in sweat chloride, nasal potential, and intestinal current to see if the drugs improve cell function. About 500 patients already taking these drugs will partici…

This study looks at whether a computer program can analyze data already collected in hospitals to help diagnose sepsis and septic shock more quickly. Researchers will study the records of 10,000 ICU patients to see if the program can speed up diagnosis and improve outcomes. The g…

This study looks at why people with multiple sclerosis (MS) feel so tired. Researchers will use a gentle brain stimulation method called tDCS to see if it changes brain activity and inflammation linked to fatigue. About 84 adults with relapsing-remitting MS will take part, with s…

This study looks at medical records from up to 1 million patients who had surgery or intensive care at a major hospital in Berlin. Researchers will use computer analysis to find patterns in routine data that are linked to better or worse patient outcomes. The goal is to learn how…

This study looks at whether eating only during a specific time each day (time-restricted eating) for four weeks can improve how well older adults respond to flu and COVID-19 vaccines. Researchers will measure changes in immune cell activity and body composition in 24 healthy volu…

This study tests whether adding realistic smells to virtual reality (VR) scenes is a safe and acceptable way to study alcohol cravings in people with alcohol dependence. Researchers will have 20 participants experience VR environments with alcohol-related scents and measure their…

This study looks at whether a single dose of estradiol (a hormone) can lower the number of intrusive, unwanted memories after a traumatic experience. Healthy female volunteers will watch a stressful film and then record any intrusive memories over the next four days. The goal is …

This study aims to find out why some people who have been in the intensive care unit (ICU) do not attend their follow-up appointments. Researchers will look at the medical records of 2,500 patients to see who came to their first post-ICU checkup and who didn't. The goal is to lea…

This study reviews medical records from 26,000 adults in intensive care to see if following specific quality care steps leads to better patient outcomes and lower hospital costs. Researchers will analyze data on treatments, costs, and patient health to find which care processes w…

This study looks at how preparing children differently before heart surgery or catheterization can lower their stress and anxiety. Researchers will observe 100 children and their families, measuring anxiety levels and other experiences. The goal is to find ways to make the hospit…

This study looks at how pregnant and non-pregnant patients recover after being in the intensive care unit (ICU) for COVID-19 and lung failure. Researchers will track problems with movement, thinking, and mental health for up to 3 years after the ICU stay. The goal is to better un…

This study interviews 60 prostate cancer patients and their relatives to learn about their needs during and after radiation therapy. It also explores their thoughts on prehabilitation, which is a program to prepare patients for treatment. The goal is to gather information to impr…

This study follows up with 434 older adults from the BioCog study to see how their thinking and memory skills have changed over 7 to 10 years. Participants take cognitive tests on a web app from home and answer questions about how easy it is to use. The goal is to understand long…

This study looks back at medical records of 200 people with severe lung failure (ARDS) to see if their immune system affects their risk of getting extra infections. Researchers will check for reactivation of viruses like herpes and measure different immune cells. The goal is to f…

This study will observe 2500 adults with chronic diseases who receive Traditional, Complementary and Integrative Medicine (TCIM) during hospital stays at three German centers. The goal is to measure how treatments like hyperthermia, exercise, mind-body therapy, and nutrition affe…

This study is looking at how much protein cancer patients eat before, during, and after radiation therapy, and whether that affects their muscle mass and quality of life. Researchers will track 175 adults aged 45 and older who are receiving radiation for various tumors. The goal …

This study tracks brain activity in 25 people with dystonia who are getting deep brain stimulation (DBS). Researchers want to find brain signals that show how well the treatment is working, so therapy can be adjusted faster and more precisely. Participants will use a special pace…

This study follows 200 adults who have had or will have a procedure to fix a leaky or narrowed right heart valve. Researchers will check participants' health through blood tests, heart ultrasounds, and medical records for two months after the procedure. The goal is to learn which…

This study looks at whether increasing dopamine can help with motivation and movement problems in people with major depression who have signs of inflammation. Researchers will give a dopamine-boosting drug or a placebo to 165 participants (depressed patients and healthy volunteer…