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Blood clot vs sponge: which heals wisdom teeth better?

NCT ID NCT07530068

Symptom relief Sponsor: Gazi University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether placing platelet-rich fibrin (PRF) made from the patient's own blood or an absorbable collagen sponge into the socket after wisdom tooth removal improves healing. Twenty-nine healthy adults with impacted lower wisdom teeth on both sides took part. Each side received one of the two treatments, and the researchers measured bone healing, pain, and swelling afterward.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich fibrin (PRF) and absorbable collagen sponge
What this could lead to
If PRF proves better, it could become a standard way to improve healing and reduce pain after wisdom tooth extraction.
What could go wrong
This is a small, completed study with only 29 participants, so results may not apply to everyone. The benefits of PRF over collagen sponge may be minor.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

29 people

The number who actually took part.

Started

Feb 2025

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Presence of bilaterally impacted mandibular third molars * Indication for extraction due to recurrent pericoronitis, non-restorable caries, or periodontal or orthodontic reasons * Age between 18 and 30 years * Systemically healthy individuals Exclusion Criteria: * Presence of acute infection or pathology in the surgical region * Systemic or immunological disease * Uncontrolled diabetes mellitus * History of chemotherapy or radiotherapy * Use of anticoagulants, steroids, or medications affecting bone metabolism * Pregnancy * Smoking

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Conditions

The condition(s) this trial relates to.

injury Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impacted mandibular third molar Postoperative pain Wound healing

Contacts and locations

Locations

  • Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey

    Ankara, Ankara, 06490, Turkey (Türkiye)

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