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New nerve block could cut opioid use for liver donors

NCT ID NCT07233096

Symptom relief Sponsor: Istinye University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a special nerve block, called a rectus-intercostal fascial plane block, can reduce pain and the need for morphine in people who donate part of their liver. Sixty-four donors were randomly assigned to receive either the nerve block plus standard painkillers or standard painkillers alone. The goal was to see if the block leads to less morphine use and better pain scores in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine (a numbing medicine) given as a nerve block
What this could lead to
If it works, this nerve block could become a standard way to reduce pain and the need for strong painkillers after liver donation surgery.
What could go wrong
This is a small, single-center study with only 64 participants. The block may not provide meaningful pain relief for everyone, and there is a small risk of side effects like bruising or infection at the injection site.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

Dec 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 75 years * Patients with American Society of Anesthesiology (ASA) physical status I-II * Patients scheduled for a living donor hepatectomy Exclusion Criteria: * Allergy to local anesthetics * Coagulopathy * Skin infection at the block area * Advanced renal failure * Chronic pain syndromes * Alcohol or drug abuse * Psychiatric disorders

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Liver transplantation Living donor Postoperative pain

Contacts and locations

Locations

  • istinye University

    Istanbul, Turkey (Türkiye)

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Other studies related to the condition(s) this trial covers.