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Could a simple painkiller combo before surgery cut opioid needs?

NCT ID NCT05685342

Symptom relief Sponsor: Seoul National University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether giving a combination of acetaminophen and ibuprofen before robot-assisted prostate surgery reduces the need for strong opioid painkillers afterward. 154 men were randomly assigned to receive the drug either before or during surgery. The main goal was to measure total opioid use in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acetaminophen/Ibuprofen fixed-dose combination (Maxigesic)
What this could lead to
If successful, this could show that giving painkillers before surgery reduces the need for strong opioids, leading to fewer side effects and faster recovery.
What could go wrong
This is a small, completed study with 154 participants, so results may not apply to all patients. The benefit may be modest and not change standard practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

154 people

The number who actually took part.

Started

Feb 2023

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 80 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled to undergo elective robot-assisted radical prostatectomy under general anesthesia * American Society of Anesthesiologists (ASA) physical classification I-II * Consent to IV-patient controlled analgesia use * Willingness and ability to sign an informed consent document Exclusion Criteria: * Who do not understand or agree with our study * American Society of Anesthesiologists (ASA) physical classification III-IV * Chronic usage of opioid analgesics * Moderate to severe pain with other cause before surgery * Allergies to anesthetic or analgesic medications used in this study * Anticipated blood loss larger than 2 liters * Need for intensive care after surgery * History of gastric ulcer or gastrointestinal bleeding * History of liver failure, renal failure or heart failure * Current alcoholism * Taking anti-coagulation drugs or history of coagulation disease * History of bronchial asthma * Medical or psychological disease that can affect the treatment response * Taking barbitutate or tricyclic antidepressant

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain

Contacts and locations

Locations

  • Seoul National University Hospital

    Seoul, Seoul, KS013, South Korea

More trials for these conditions

Other studies related to the condition(s) this trial covers.