Could a simple painkiller combo before surgery cut opioid needs?
NCT ID NCT05685342
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether giving a combination of acetaminophen and ibuprofen before robot-assisted prostate surgery reduces the need for strong opioid painkillers afterward. 154 men were randomly assigned to receive the drug either before or during surgery. The main goal was to measure total opioid use in the first 24 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Acetaminophen/Ibuprofen fixed-dose combination (Maxigesic)
What this could lead to
If successful, this could show that giving painkillers before surgery reduces the need for strong opioids, leading to fewer side effects and faster recovery.
What could go wrong
This is a small, completed study with 154 participants, so results may not apply to all patients. The benefit may be modest and not change standard practice.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Seoul National University Hospital
Seoul, Seoul, KS013, South Korea