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Could a simple painkiller before surgery cut stronger drug use?

NCT ID NCT07368790

Symptom relief Sponsor: Queen Savang Vadhana Memorial Hospital, Thailand Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving paracetamol (acetaminophen) through an IV before a total abdominal hysterectomy reduces the need for morphine afterward. Forty women aged 30-50 took part. The goal was to see if they used less morphine and felt less pain in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
paracetamol (acetaminophen)
What this could lead to
If it works, this could mean less morphine needed after hysterectomy, reducing side effects like nausea or drowsiness.
What could go wrong
This is a small, completed trial with only 40 participants. The results may not apply to everyone, and paracetamol might not reduce morphine use significantly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Oct 2024

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria 1. Female patients aged 30-50 years. 2. Scheduled to undergo total abdominal hysterectomy (TAH) at Queen Savang Vadhana Memorial Hospital at Sriracha 3. No history of allergy to paracetamol (acetaminophen) or morphine. 4. Normal renal function: serum creatinine ≤ 1.2 mg/dL. 5. No severe or recurrent liver disease, and AST or ALT ≤ 3× the upper limit of normal. 6. Able to communicate in Thai, complete the questionnaire, and provide written informed consent (no restriction on race or nationality). Exclusion criteria 1. Incomplete medical record. 2. Use of any analgesic medications within 24 hours preoperatively. 3. Receipt of any postoperative analgesic other than morphine during the first 24 hours after surgery. 4. Withdrawal from the study. 5. Adverse reaction after administration of the study drug. 6. Concomitant surgery involving other organs (e.g., ovary or lymph nodes).

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain

Contacts and locations

Locations

  • Queen Savang Vadhana Memorial Hospital, Thai Red Cross Society, Jermjomphon street, Chonburi, 20110,

    Chon Buri, Thailand

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