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Could a common numbing drug cut opioid use after liver surgery?

NCT ID NCT05153785

Symptom relief Sponsor: Lund University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving lidocaine through a vein during and after liver surgery can reduce pain and the need for strong painkillers like opioids. 124 adults having minor liver surgery were randomly assigned to receive either lidocaine or a placebo (salt water). Researchers measured how much opioid pain medication patients used and their pain scores over several days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lidocaine
What this could lead to
If it works, this could offer a way to manage pain after liver surgery with fewer opioids, potentially speeding recovery.
What could go wrong
This is a small, completed Phase 2/3 trial. Lidocaine may not reduce pain or opioid use significantly, and it carries risks like heart or nerve issues in some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

124 people

The number who actually took part.

Started

Nov 2021

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 yy * Patient planned for minor hepatectomy * Signed informed consent Exclusion Criteria: * Pregnancy * Cirrosis * ASA\>3 * Elevated liver enzymes * AV-block \>1, without pacemaker * WHO class \>2 * Allergy against Lidocain or other amid-type local anasthesia * Heart failure * Epilepsy * Treatment with class III anti-arythimic medication * Preoperative ongoing opioid usage * Use of : Erythromycin, clarithromycin, Fluvoxamine, Cimetidine, ciprofloxacin, antivirala-HIV-läkemedel or imidazol the week before surgery.

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Conditions

The condition(s) this trial relates to.

liver cancer Liver Neoplasms opioid abuse Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Liver cancer Liver metastases Opioid use Postoperative pain

Contacts and locations

Locations

  • Skåne University Hospital of Lund

    Lund, Skåne County, 22185, Sweden

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