POSTOPERATIVE PAIN

This study aims to understand how a new pain medication called Anrikefon is processed in the bodies of older adults after abdominal surgery. It will enroll 30 participants aged 65 and older to measure the drug's levels in their blood. The goal is to gather information to help det…

This study aims to find the best method to manage pain after open-heart surgery. Researchers will compare two different ultrasound-guided nerve-block techniques in 80 adult patients. The main goal is to see which method reduces the need for strong opioid painkillers in the first …

This study is testing if a TENS device, which uses mild electrical pulses on the skin, can help reduce pain and improve sleep for people recovering from hernia surgery. 80 adults having hernia surgery will be randomly assigned to receive either TENS treatment along with usual car…

This study aims to find which of two nerve-blocking techniques provides better pain relief after chest surgery. Researchers will compare the Rhomboid-Intercostal Block (RIB) and Thoracic Paravertebral Block (PVB) in 60 adults undergoing video-assisted chest surgery. Both methods …

This study is testing whether soaking feet in warm water helps people feel better after having their gallbladder removed through keyhole surgery. Researchers want to see if this simple, drug-free method can reduce pain and help patients' digestive systems return to normal faster.…

This study is testing if simple, non-drug methods can help patients feel less pain and anxiety when a chest tube is removed after surgery. Researchers will compare using a gentle vibrating device near the tube site, doing guided breathing exercises, or just receiving standard car…

This study compares two different nerve-blocking techniques used to manage pain after knee replacement surgery. Researchers want to see if a newer method (BiFeS block) works as well as a more established one (iPACK block) for reducing pain and helping patients move sooner after s…

This study aims to find the best way to manage pain after shoulder surgery. Researchers will compare two common nerve-blocking techniques given before surgery to see which one provides better pain relief and reduces the need for strong painkillers in the first day after the opera…

This study compares two ways to give pain-blocking injections during double knee replacement surgery. Patients will receive one type of injection from their surgeon on one knee and a different type from an anesthesiologist on the other knee. Researchers want to see if the surgeon…

This study aims to find out if taking acetaminophen (Tylenol) as a pill or through an IV is better for managing pain after spinal fusion surgery. It will involve 180 adults having this specific back surgery. Researchers will compare pain levels, opioid use, and recovery times bet…

This study is testing whether a combination nasal spray (dexmedetomidine-esketamine) given during surgery can better manage pain in children recovering from tonsil and adenoid removal. It will involve 160 children aged 3 to 7 years. The goal is to see if this approach reduces pai…

This study aims to see if spraying a numbing medicine (bupivacaine) over the diaphragm during surgery can reduce shoulder pain that often occurs afterward. It will involve 100 patients having planned, non-cancer gynecologic surgery at Cedars-Sinai. Participants will be randomly a…

This study is comparing two methods to manage pain after a common children's ear surgery. Researchers want to see if a targeted numbing shot near the ear (Nerve of Arnold block) works as well as the standard pain shots, which include an opioid. The goal is to find a way to contro…

This study aims to find which of two nerve-block injection techniques works better for pain relief after breast augmentation surgery. Researchers will compare a commonly used method with a newer technique in 60 women undergoing the procedure. They will measure pain levels, pain m…

This study compares two different nerve block techniques to see which provides better pain relief with fewer opioid medications after laparoscopic gallbladder removal surgery. Researchers will randomly assign 147 patients to receive either a paravertebral block, an external obliq…

This study is testing whether two types of breathing exercises can help patients feel better after breast cancer surgery. Researchers will compare pranayama (alternate nostril breathing) and pursed-lip breathing against standard care to see if they reduce pain and anxiety. The go…

This early-stage study is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' is safe and practical to give to adults recovering from major trauma surgery who also have opioid use disorder. Researchers want to see if this one-time dose can help …

This study is testing whether a specific nerve block given before surgery can reduce pain and the need for strong painkillers after a laparoscopic hysterectomy. Sixty women having this common surgery will be randomly assigned to receive either the nerve block or standard pain car…

This study is testing whether a simple breathing exercise called 'Box Breathing' can help older adults recover better from knee replacement surgery. Researchers will see if this easy, at-home technique can reduce the body's stress response after surgery, which may lead to less pa…

This study is testing two different non-opioid methods to help manage pain after brain tumor surgery. It will involve 2,000 patients to see if using a local nerve block before surgery or a specific sedative during surgery can reduce the need for strong opioid painkillers afterwar…

This study aims to find which of two common pain-numbing injections works better for recovery after keyhole gallbladder surgery. Researchers will randomly assign patients to receive one of the two nerve-block techniques while they are asleep at the end of the operation. The main …

This study is testing a new type of nerve-block injection, given before surgery, to see if it can better control pain after heart surgery. Researchers will compare pain levels and opioid painkiller use in 120 adults who receive the new block versus standard care. The goal is to f…

This study is testing a new combination of nerve blocks to better manage pain after open-heart surgery. Researchers want to see if this approach reduces the need for strong opioid painkillers, which can cause side effects like nausea and breathing problems. The goal is to help pa…

This study is testing if applying a gel called RADA16 during tonsil removal surgery helps children recover better. Researchers want to see if the gel reduces pain, bleeding, and the need for strong painkillers after the operation. About 134 children aged 3-17 will be randomly ass…

This study tests whether gentle electrical stimulation on the ear can help reduce pain and the need for strong painkillers after complex spine surgery. Researchers will enroll 98 patients having major spinal operations. Participants will be randomly assigned to receive either rea…

This study is testing a new technique to better control pain after minimally invasive colon surgery. During the operation, surgeons will inject a numbing medicine around specific nerves that carry pain signals from the bowels. The goal is to see if this targeted 'nerve block' hel…

This study aims to find the best way to manage pain after minimally invasive stomach cancer surgery. It will compare two established methods: a numbing injection guided by ultrasound versus a special gel applied directly to the surgical site. The goal is to see which method provi…

This study is testing whether a specific type of nerve block (an Erector Spinae Plane block) can better control pain after spinal fusion surgery. Researchers will compare two different numbing medications to see which one helps patients use fewer opioid painkillers, feel less pai…

This study is testing if a new type of ultrasound-guided nerve block, given on both sides of the abdomen, can help control pain and reduce the need for opioid painkillers after laparoscopic gallbladder removal. Researchers will compare 56 patients who receive the nerve block to t…

This study is testing whether using hydrogen-rich water for mouth care helps patients recover better after oral cancer surgery. It will compare hydrogen water against plain water in 36 patients who had reconstructive surgery. Researchers will measure pain, mouth inflammation, and…

This study aims to find out if the type of cleaning solution used during a root canal affects how much pain a patient feels the next day. Researchers will compare two common solutions—chlorhexidine and a bleach-based solution—in 90 adults getting root canals. Participants will ra…

This study is testing a combination approach to manage pain after brain tumor surgery. It will compare different methods of delivering pain medication to see which best reduces the need for strong opioid drugs. The goal is to find a safer, more effective way to control pain and s…

This study aims to find out if a patient's position during a pain-blocking injection affects how well it works after chest surgery. Researchers will compare the injection given while patients are sitting up versus lying on their side. The goal is to see which position provides be…

This study is testing whether a special pillow placed behind the shoulder can help reduce pain and improve sleep for people recovering from surgery to repair a torn rotator cuff. Researchers will compare patients who choose to use the pillow with those who do not, tracking their …

This study aims to find which anesthesia method provides better pain relief after knee replacement surgery. Researchers will observe 50 patients receiving different anesthesia combinations to see which one results in less pain and requires fewer pain medications during the first …

This is an early safety study for a new pain medication called KHN702 tablets. It will test if the drug is safe and can help reduce moderate to severe pain in the first 48 hours after surgery. The study will involve 24 patients who will receive either the new drug or a placebo (a…

This study aims to find which of two established nerve block techniques provides better pain relief after open hernia repair surgery. Researchers will compare two methods—one injected near the spine and one near the ribs—in 50 patients. The goal is to reduce post-surgery pain, na…

This study compares two different nerve block techniques for managing pain after laparoscopic gallbladder removal surgery. Researchers will randomly assign 124 adult patients to receive either the M-TAPA or ESPB nerve block before surgery. They'll measure which method provides be…

This study is testing if rinsing the abdomen with salt water during a specific type of scarless hysterectomy (vNOTES) can further reduce pain after surgery. Researchers want to see if this simple step helps more than just using low gas pressure during the procedure alone. They wi…

This study aims to find which of two ultrasound-guided nerve block techniques works better to control pain after a cesarean section. Researchers will compare the Transversalis Fascia Plane block and the Erector Spinae Plane block in 60 women having planned C-sections. The main go…

This study is testing whether a simple vibration tool can help control pain after surgery for a broken wrist. Researchers want to see if this non-drug approach can reduce patients' pain and their need for opioid pain medication. The study will involve 100 patients who are receivi…

This study looks back at medical records to compare three different approaches to managing pain after breast removal surgery. Researchers will examine pain levels, opioid medication use, and patient satisfaction in 66 women who had surgery between October 2024 and 2025. The goal …

This study is testing if adding a specific nerve block to standard pain medicine helps people feel better after back surgery. Fifty patients having planned spine surgery will be randomly chosen to get either the new nerve block plus standard care or just standard care alone. The …

This study is testing a new type of nerve block injection to see if it can better control pain after major abdominal surgeries like gallbladder or liver operations. Researchers will compare patients who get the new block plus standard pain care against those who get standard care…

This study is testing whether a specific nerve-blocking injection can help people recover better after hip replacement surgery. Researchers will compare recovery quality, pain levels, and medication use between patients who receive the nerve block and those who get standard pain …

This study is testing if a Botox injection given a week before hemorrhoid surgery can reduce pain after the operation. Researchers will compare Botox to a placebo injection in 292 adults with severe hemorrhoids. The main goal is to see if relaxing the anal muscle with Botox leads…

This study compares two different nerve block techniques to see which provides better pain relief after hip surgery. Sixty patients will be randomly assigned to receive either the Quadroiliac Plane Block or the Suprainguinal Fascia Iliaca Compartment Block during their procedure.…

This study aims to see if a patient's pain from getting an IV needle and their anxiety before surgery can help predict how much pain they will feel after a common gallbladder removal operation. Researchers will observe 100 adults having this elective surgery, measuring their need…

This study aims to understand how patients feel about routine pain monitoring after elective surgery. Researchers will survey and interview 300 patients to learn whether they view these checks as supportive or stressful, and how these perceptions affect their trust in nurses, anx…