POSTOPERATIVE PAIN

This study tests a dental implant method for people with a narrow jawbone. The procedure splits the bone and places an implant covered with a special growth factor membrane to help healing. Ten adults aged 20-50 with good oral health will be enrolled. The study will measure pain …

This study compares a nerve block (PENG block) to spinal morphine for pain control after total hip replacement. About 180 adults having hip surgery will receive one of the two treatments. The goal is to see which method provides better pain relief, reduces the need for extra pain…

This study looks at whether a hot water foot bath can reduce pain and help people pass gas sooner after laparoscopic gallbladder removal. About 62 adults will be randomly assigned to receive the foot bath or standard care. The goal is to find a simple, drug-free way to improve re…

This study tests if using a cold anti-inflammatory rinse inside the tooth after root canal treatment can lower pain. Sixty adults with tooth infections will receive either a cold rinse or a room-temperature rinse. The goal is to see which approach reduces pain and inflammation be…

This study compares two types of nerve blocks to control pain after laparoscopic gallbladder removal. About 60 adults aged 18-65 will receive one of the two blocks. The goal is to see which block provides better pain relief and reduces the need for strong painkillers.

This study tests whether a special nerve block called M-TAPA can reduce pain and the need for strong painkillers after laparoscopic hysterectomy. About 60 adults having this surgery will be randomly assigned to receive either the nerve block plus standard care or standard care al…

This study compares two ultrasound-guided nerve blocks to manage pain after heart surgery. 80 adults having planned heart surgery will receive one of the two blocks alongside standard anesthesia. The goal is to see which block reduces the need for strong painkillers (opioids) and…

This study tests whether a single injection of dexamethasone given before removing an impacted lower wisdom tooth can lessen pain and difficulty opening the mouth afterward. 268 adults aged 18 to 55 will be randomly assigned to receive either the injection or no extra medication.…

This study tests a new type of nerve block (External Oblique Intercostal Plane Block) to see if it can reduce pain and the need for strong painkillers after major upper abdominal surgery. About 78 adults having laparoscopic surgery on their stomach, liver, gallbladder, or pancrea…

This study tests an experimental pain medicine called CPL-01 for people who have bunion surgery. About 112 adults will receive either the drug or a placebo after their operation. Researchers will track how much pain they feel and whether they need extra painkillers.

This study will compare two types of nerve blocks (SPSIP and ESP) to see which one works better for pain after surgery to fix broken ribs. Sixty adults having rib surgery will be randomly assigned to receive one of the two blocks. The main goal is to measure pain levels in the fi…

This study tests whether injecting tramadol, with or without dexamethasone, into the knee after arthroscopy reduces pain better than a placebo. About 135 adults having minor knee surgery will be randomly assigned to one of three groups. The goal is to find a simple way to improve…

This study tests whether a surgeon can give a pain-relieving nerve block during knee replacement surgery as effectively as an anesthesiologist using ultrasound. 48 adults having both knees replaced will get one type of block on each knee. The goal is to see if the surgeon's metho…

This study compares two ultrasound-guided nerve blocks (TFP and ESP) for pain relief after cesarean section. Sixty women having a planned C-section will receive one of the two blocks, and researchers will measure their pain scores and how much opioid pain medicine they need. The …

This study compares two types of nerve blocks to see which provides better pain relief after open gallbladder removal. Sixty-six adults having this surgery will receive one of the two blocks along with standard anesthesia. The goal is to find which method reduces pain and the nee…

This study compares two pain-blocking techniques used during breast surgery to see which is easier for doctors to perform and which helps patients feel more comfortable after surgery. About 64 adults having a mastectomy will take part. The goal is to improve recovery and reduce p…

This study tests a new type of nerve block (called r-PVB) to see if it can reduce pain and help people recover faster after stoma closure surgery. About 250 adults having this surgery will either get the new block or standard care. The goal is to lower pain scores and improve ove…

This study compares two types of nerve blocks (M-TAPA and ESPB) to see which provides better pain relief after laparoscopic gallbladder removal. About 124 adults having elective surgery will be randomly assigned to receive one of the two blocks. The main goal is to measure total …

This study looks at whether rinsing the belly with salt water during a low-pressure, scarless hysterectomy (vNOTES) can lower pain and the need for painkillers after surgery. About 94 women scheduled for this procedure will be randomly assigned to receive the washout or not. The …

This study compares two types of nerve blocks to control pain after laparoscopic sleeve gastrectomy (weight-loss surgery). Sixty adults aged 18-65 with a BMI over 35 will be randomly assigned to receive one of the two blocks. The goal is to see which block provides better pain re…

This study looks at whether a special nerve block given during left-sided colon surgery can better control pain and reduce the need for strong painkillers like opioids. About 400 adults having minimally invasive colon surgery will be observed. The goal is to see if this approach …

This study compares two common pain relief methods after laparoscopic gallbladder removal: injecting numbing medicine into the surgical cuts versus using an ultrasound to guide numbing medicine around the stomach muscles. The goal is to see which method better reduces pain and th…

This study compares two types of nerve blocks to see which one provides better pain relief after open ventral hernia repair. Fifty adults scheduled for this surgery will receive one of the two blocks, and researchers will measure how much extra pain medicine they need in the firs…

This study tests whether a magnesium drip given after a C-section can lower pain and help new mothers recover faster. About 150 women having planned or non-urgent C-sections will be randomly assigned to receive either magnesium or a saltwater solution. Neither they nor their doct…

This study compares two types of nerve blocks (QIPB and SIFICB) to see which one works better for pain after hip surgery. About 60 adults will take part. The goal is to find which method reduces pain and the need for extra pain medicine.

This study looks at whether using a vibrating device or doing breathing exercises right before a chest tube is taken out can help lower pain and anxiety. About 70 adults who need a chest tube removed after surgery will be split into three groups: one gets vibration, one does brea…

This study looks at whether a device called TENS, which uses mild electrical pulses, can help reduce pain and improve sleep after inguinal hernia surgery. About 80 adults will either receive TENS or standard care after their operation. Researchers will measure pain levels and sle…

This study looks at whether listening to music and using Emotional Freedom Techniques (a simple tapping method) can help people recover more comfortably after knee arthroscopy. The goal is to reduce pain, fear of moving, and the risk of falling. About 85 adults having knee surger…

This study compares two common nerve block methods for shoulder surgery pain. 60 adults will get either one block or a combination of two blocks before surgery. Researchers will track pain levels, painkiller use, and side effects for 24 hours after surgery to see which method wor…

This study tests if a special nerve block (external oblique intercostal block) can reduce pain and the need for strong painkillers after gallbladder removal surgery. About 56 adults having planned laparoscopic gallbladder surgery will either get the nerve block or no block. The m…

This study tests a new type of nerve block (r-PVB) to see if it reduces pain and helps patients recover faster after laparoscopic gallbladder removal. The trial will involve 250 adults having planned surgery for non-cancerous gallbladder disease. The approach uses a single inject…

This study tests whether adding a third nerve block to two standard ones can better control pain after hip surgery. Many patients still feel pain in the back of the hip with standard blocks. Researchers will compare pain scores and the need for extra pain medicine in 50 adults un…

This early-stage study tests a new medicine called SYH9089 for pain after abdominal surgery. About 60 adults will receive either the new drug, an active painkiller, or a placebo. Researchers will check safety and how well it controls pain over 14 days.

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce pain and the need for strong painkillers after complex spinal surgery. About 98 adults will be randomly assigned to receive either the real stimulation or a sham (fake) treatm…

This study compares two types of nerve blocks (SAP and SPSIP) to see which provides better pain relief after breast surgery (mammoplasty). Sixty women aged 18-85 will be randomly assigned to receive one of the blocks. Researchers will measure pain levels, opioid use, and patient …

This study compares two ways of giving the painkiller acetaminophen (Tylenol) after lower back fusion surgery: by mouth or through an IV. About 180 adults will be randomly assigned to one of the two groups. The goal is to see which method provides better pain control and helps pa…

This study tests if using scalp nerve blocks and a sedative drug called dexmedetomidine can reduce the need for strong opioid painkillers and prevent confusion after brain tumor surgery. About 2000 adults having elective brain surgery will be randomly assigned to one of four trea…

This study compares a nerve block (injecting numbing medicine near the ear) to standard pain shots (fentanyl and ketorolac) for children aged 6 months to 6 years having ear tube surgery. The goal is to see if the nerve block works just as well for pain control while avoiding opio…

This study tests whether a special nerve block (ESP block) can reduce pain and the need for strong painkillers after spinal fusion surgery. About 75 adults will receive either a standard numbing medicine or a longer-acting version. Researchers will measure pain scores, opioid use…

This study compares two common nerve block techniques to see which one helps patients recover better after keyhole gallbladder removal. 76 adults having planned surgery will receive one of the two blocks while asleep. The main goal is to measure recovery quality on the first day …

This study looks at the best time to give a pain drug called Anrikefon to adults having gallbladder removal surgery. About 274 people will get the drug either before anesthesia or after the gallbladder is removed. The goal is to see which timing reduces pain better and helps pati…

This study tests two methods to control pain after keyhole stomach surgery for cancer. One group gets a standard ultrasound-guided nerve block, while the other gets a special gel applied directly to the surgical site that slowly releases pain medicine. The goal is to see which ap…

This study compares two numbing techniques—RIB and PVB—to see which controls pain better after chest surgery. Sixty adults having a specific type of chest surgery will be randomly assigned to one of the two blocks. Pain levels will be tracked for 24 hours after surgery to find th…

This study looks at whether two types of breathing exercises—pranayama and pursed-lip breathing—can help reduce pain, anxiety, and improve vital signs in people recovering from breast surgery. About 126 adults having a mastectomy will be randomly placed into one of three groups: …

This study compares two types of nerve blocks to see which provides better pain relief after breast cancer surgery that includes removing lymph nodes. Sixty women aged 18-65 will be randomly assigned to receive one of the two blocks. The goal is to reduce pain and the need for st…

This study tests two types of nerve blocks to see which one controls pain better after laparoscopic sleeve gastrectomy, a weight-loss surgery. Sixty adults will receive one of the two blocks, and their pain levels, opioid use, and recovery quality will be tracked for 24 hours. Th…

This study tests whether a special vibration tool can improve pain control after surgery for a broken wrist (distal radius fracture). About 100 adults who have had this surgery will use the device and report their pain levels and how many pain pills they take. The goal is to see …

This study looks at whether rinsing with hydrogen water can help reduce pain, swelling, and mouth sores in people recovering from oral cancer surgery that involved rebuilding part of the mouth with a skin flap. About 36 adults will be randomly assigned to receive either hydrogen …

This study tests whether a special nerve block (M-TAPA) can reduce pain and the need for strong painkillers after open-heart surgery. About 80 adults having elective open-heart surgery will receive either the block plus standard care or standard care alone. The goal is to see if …

This study looks at whether adding a steroid called dexamethasone to a common pain medicine helps control pain after shoulder surgery. About 70 adults having shoulder arthroscopy will get a nerve block and either the steroid or a placebo. The main goal is to see how long it takes…

This study looks at 50 adults having knee replacement surgery to see which type of anesthesia works best for controlling pain and reducing the need for painkillers in the first two days after surgery. Participants will get either general anesthesia or spinal anesthesia, each comb…

This study looks at whether adding electroacupuncture to standard numbing medicine can reduce pain and stress during wisdom tooth surgery. Sixty adults aged 25-35 will be split into three groups: real electroacupuncture, fake acupuncture, or no acupuncture. Researchers will measu…

This study tests whether giving a single dose of methadone at the start of surgery can provide better pain relief and faster recovery compared to standard short-acting opioids. About 400 adults having intermediate-risk noncardiac surgery will take part. The main goal is to see if…

This study tests if spraying a numbing medicine (bupivacaine with epinephrine) over the diaphragm can reduce shoulder pain after laparoscopic gynecologic surgery. About 100 women will receive either the numbing spray or a saltwater spray during surgery. Researchers will compare p…

This study compares two types of nerve blocks to control pain after video-assisted lung surgery. Sixty adults will receive either a serratus posterior superior intercostal plane block or a deep serratus anterior plane block. The goal is to see which block provides better pain rel…

This study tests two different medicines (dexmedetomidine and low-dose ketamine) to see which one works better for pain control after weight-loss surgery. 90 adults will be randomly assigned to receive one of these medicines or a placebo during surgery. The goal is to find a safe…

This study tests whether natural herbal medicines like propolis and green tea can reduce pain and sudden flare-ups after root canal retreatment better than the standard calcium hydroxide paste. Forty adults with failed root canals on single-rooted teeth will be randomly assigned …

This study compares two common root canal cleaning solutions—chlorhexidine and sodium hypochlorite (bleach)—to see which one leads to less pain the day after the procedure. About 90 adults needing a root canal will be randomly assigned to one of the two solutions. Participants wi…

This study compares two types of nerve blocks (iPACK and BiFeS) to see which one provides better pain relief after total knee replacement. About 100 adults scheduled for surgery will receive one of the two blocks, and researchers will measure pain levels, opioid use, and how quic…

This study looks at whether a simple breathing exercise called box breathing can help older adults (65+) recover from knee replacement surgery. The goal is to see if it reduces stress, pain, anxiety, and improves overall recovery. Thirty-two participants will either practice box …

This study tests a new type of nerve block (SPSIPB) to see if it can reduce pain and the need for strong painkillers after heart surgery. About 120 adults having planned heart surgery through a chest incision will be randomly assigned to get either the nerve block or standard car…

This early-stage trial tests whether KHN702 tablets can safely ease moderate to severe pain after surgery. About 24 adults will receive either the drug or a placebo, and researchers will measure pain relief over 48 hours. The goal is to see if this new pill works and is safe enou…

This study looks at whether using a pillow placed behind the shoulder after rotator cuff repair surgery can lower pain and improve sleep. About 126 adults aged 40-70 who are having this surgery will choose whether to use the pillow. Their pain, sleep quality, and shoulder functio…

This study tests whether adding a second nerve block to the standard one can better control pain after hip replacement surgery. Forty adults having hip replacement will be randomly assigned to receive either the standard block or the standard plus an extra block. Researchers will…

This early-stage trial will test whether a single dose of psilocybin (the active ingredient in magic mushrooms) is safe and practical for adults with opioid use disorder who are recovering from trauma surgery. Seventy participants will receive the drug during their hospital stay …

This study tests a combination of pain medicines and local numbing to improve pain control after brain tumor surgery. The goal is to reduce the need for strong opioids, which can cause side effects and complications. About 2,000 adults having planned brain surgery will take part.…

This study watches how anesthesia residents place epidural catheters using two common methods—loss of resistance and hanging drop. Researchers will track which method works on the first try and how often complications happen. About 440 adults having planned surgery will take part…

This study aims to see if the pain you feel when getting an IV started and your anxiety before surgery can predict how much pain you'll have after gallbladder removal. Researchers will measure these factors in 100 adults and track their pain for 12 hours after surgery. The goal i…

This study will check if ultrasound measurements of the belly muscle thickness can help predict how much opioid pain medicine older patients need after abdominal surgery. Researchers will measure the muscle before surgery and track pain scores and painkiller use for 24 hours afte…

This study looks back at medical records of 66 women who had a mastectomy to see which pain relief method worked best: standard pain medication, a nerve block called rhomboid intercostal block (RIB), or a combination of RIB with another nerve block. Researchers will check pain sc…

This study looks at whether negative pressure wound therapy (a vacuum device used to help heal severe war wounds) is linked to ongoing pain six months after injury. Researchers will follow 150 adults with war-related soft tissue injuries to track pain levels and other factors lik…

This study looks at a new way to measure pain in newborns after surgery using a skin monitor. Since babies can't tell us they're in pain, doctors currently use checklists and vital signs. The skin monitor tracks stress signals continuously and may be more accurate. About 100 babi…

This study will observe 250 children aged 2 to 8 who are having urogenital surgery. Researchers want to see if the length of time they fast (no food or drink) before the operation affects their pain and agitation when they wake up. The goal is to find the best fasting time to imp…

This study looks at how a new pain drug, Anrikefon, works in people aged 65 and older after laparoscopic abdominal surgery. Thirty participants will receive the drug and have their blood levels measured. The goal is to understand how the drug behaves in older adults, not to prove…

This study looks at whether the position you are in when you get a nerve block for chest surgery changes how well it works. 90 adults having video-assisted chest surgery will be randomly placed in either a sitting or lying-on-the-side position for the block. Researchers will meas…

This study involves 14-18 healthy volunteers who will receive three different types of quadratus lumborum blocks on separate days. The goal is to compare how each block affects skin sensation and leg strength. Results will help doctors choose the best block for postoperative pain…

This study looks at 100 adults having their thyroid gland removed to see how different pain relief methods affect recovery and swallowing pain. Researchers will observe patients under normal care without giving any new treatments. The goal is to learn which approach leads to bett…