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Which nerve block eases mastectomy pain best? a Head-to-Head trial

NCT ID NCT07737132

Symptom relief Sponsor: Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial compares two ultrasound-guided nerve blocks for pain after modified radical mastectomy: the newer serratus posterior superior intercostal plane block (SPSIPB) and the established serratus anterior plane block (SAPB). Seventy women undergoing mastectomy will receive one of the two blocks before surgery. The goal is to see which provides better pain relief, reduces opioid use, and improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
two types of ultrasound-guided nerve blocks: serratus posterior superior intercostal plane block (SPSIPB) and serratus anterior plane block (SAPB), each using bupivacaine
What this could lead to
If one block proves superior, it could become the preferred option for managing pain after mastectomy, reducing opioid use and speeding recovery.
What could go wrong
This is a small, single-center trial with 70 patients, so results may not apply broadly. Both blocks are already in use, so the difference may be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female patients aged 18 to 65 years. * Scheduled for elective modified radical mastectomy under general anesthesia. * American Society of Anesthesiologists (ASA) physical status I-III. * Body mass index (BMI) \<35 kg/m². * Normal coagulation profile (including INR and platelet count). * Normal liver and renal function tests. * Able to understand the study procedures and provide written informed consent. Exclusion Criteria: * Known allergy or hypersensitivity to local anesthetics. * Coagulation disorders or bleeding diathesis. * Infection or inflammation at the planned block site. * ASA physical status IV or higher. * Chronic opioid use or chronic pain requiring long-term analgesic therapy. * Advanced hepatic or renal insufficiency. * Severe pulmonary disease. * Opioid use within 24 hours before surgery. * Cognitive impairment or inability to complete postoperative assessments. * Revision breast surgery. * Refusal to participate in the study.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast cancer Postoperative pain

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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