Herbal hope: propolis and green tea may beat standard care for root canal pain
NCT ID NCT07578311
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether natural medicines (propolis and green tea extract) placed inside the tooth can reduce pain and sudden flare-ups after a root canal retreatment. Forty adults with a failed root canal on a single-rooted tooth will be randomly assigned to get either the standard calcium hydroxide paste or one of the herbal options. Pain levels will be tracked for a week, and any severe pain or swelling will be recorded.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Failed previously performed endodontic treatment of single-rooted teeth. * Presence of a periapical lesion ranging from 1 mm to 2 mm in diameter. * Teeth with complete root formation. * Teeth without evidence of external or internal root resorption. Exclusion Criteria: * Pregnant females. * Patients with uncontrolled systemic diseases. * Patients currently under antibiotic or analgesic administration. * Patients presenting with facial swelling. * Teeth not indicated for endodontic retreatment (e.g., poor oral hygiene, mobile teeth, or recessed teeth).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
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How to take part
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The official record
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A doctor treating you
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