One shot of methadone during surgery could ease pain and speed recovery
NCT ID NCT07565870
First seen May 09, 2026 · Last updated Jun 23, 2026 · Updated 6 times
Summary
This phase 3 trial will test whether a single dose of methadone given at the start of surgery can improve pain control and recovery compared to standard short-acting opioids. About 400 adults having intermediate-risk noncardiac surgery will take part. The main goal is to see if patients feel better the day after surgery.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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UCI
Irvine, California, 92697, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Methadone (a long-acting opioid painkiller)
What this could lead to
If it works, this could offer a simple way to reduce pain and speed up recovery after surgery, lowering the need for other opioids.
What could go wrong
This is an early-stage trial with 400 participants, so results may not apply to everyone. Methadone can cause side effects like nausea, drowsiness, or breathing problems.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.