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Freezing nerves during heart surgery may slash opioid use

NCT ID NCT07637370

Symptom relief Sponsor: Rutgers, The State University of New Jersey Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a technique called cryoablation, where doctors temporarily freeze nerves in the chest during open-heart surgery. The goal is to see if this reduces pain, helps patients breathe deeper and cough better after surgery, and lowers the need for strong painkillers like opioids. About 100 adults having their first heart surgery will take part, and half will receive the freezing treatment while the other half gets standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: Adults aged 40 and above no upper limit. * Surgical Plan: Undergoing first-time elective cardiac surgery via full median sternotomy (e.g., CABG, AVR, MVR). * Cognitive Status: Ability to understand and provide informed consent and utilize a Numerical Rating Scale (NRS) for pain. * Baseline Pain: Preoperative chronic pain score of \< 3/10. Exclusion Criteria: * Redo Sternotomy: Previous cardiac surgery (due to adhesions and altered anatomy). * Opioid Tolerance: Preoperative daily opioid use for \>4 weeks (to avoid confounded MME requirements). * Neurological Conditions: Pre-existing intercostal neuralgia, peripheral neuropathy, or significant psychiatric disorders. * Emergency Cases: Hemodynamically unstable patients or those requiring emergency "crash" surgery. * Allergies: Known hypersensitivity to local anesthetics (if used in the control arm). * Anatomical Barriers: Severe chest wall deformities or extensive pleural adhesions.

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Conditions

The condition(s) this trial relates to.

Hyperalgesia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Median sternotomy recovery Postoperative pain Pulmonary dysfunction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Rutgers University Robert Wood Johnson University Hospital

    New Brunswick, New Jersey, 08901, United States

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