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Can a single injection before stitches cut Post-Surgery opioid use?

NCT ID NCT07753629

Symptom relief Sponsor: Seoul National University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial tests whether injecting a mixture of local anesthetics and pain relievers under the skin before closing the wound can reduce pain after orthopedic wide excision surgery for bone or soft tissue tumors. Half of the participants will receive the active mixture, while the other half will get a saline control, and neither they nor the assessors will know which. The main goal is to see if this injection lowers the amount of opioid pain medication needed in the first 24 hours after surgery, with additional measures of pain scores, nausea, and quality of recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A mixture of local anesthetics and pain relievers (ropivacaine, morphine, ketorolac, epinephrine) injected under the skin at the surgical site before wound closure.
What this could lead to
If effective, this injection could provide better pain control after bone or soft tissue tumor surgery, reducing the need for opioid painkillers and improving recovery.
What could go wrong
The trial is small and early, so results may not be conclusive. The injection might not reduce pain significantly, and there are potential risks like allergic reactions or side effects from the medications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 58 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scheduled to undergo elective orthopedic wide excision surgery under general anesthesia * American Society of Anesthesiologists (ASA) Physical Status Classification 1, 2, or 3 * Age 19 years or older Exclusion Criteria: * Unwilling to provide informed consent * History of allergy to local anesthetics * History of chronic pain * Use of opioid analgesics within 24 hours before surgery * Active infection at the surgical site

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain Wide excision

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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Other studies related to the condition(s) this trial covers.