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Can a less invasive nerve block match the gold standard for chest surgery pain?

NCT ID NCT07763249

Symptom relief Sponsor: Hospital de Clinicas de Porto Alegre Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial tests whether a paravertebral block—a numbing medicine delivered near the spine—can control pain after open chest surgery just as well as the standard epidural block. Adults having elective thoracotomy will be randomly assigned to one of the two blocks, and their pain scores will be tracked for 48 hours. The goal is to see if the paravertebral approach offers comparable relief with potentially fewer side effects like drops in blood pressure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Continuous thoracic paravertebral block (a numbing medicine delivered through a small tube near the spine) compared with continuous thoracic epidural block (a similar tube placed deeper in the back).
What this could lead to
If the paravertebral block works as well as the epidural, it could become a preferred option for chest surgery pain—possibly with less impact on blood pressure and easier movement after surgery.
What could go wrong
This is a small, early-stage comparison, and the paravertebral block might not match the epidural's pain relief. There are also risks like infection, bleeding, or nerve damage with any block.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 years or older; * Elective thoracic surgeries requiring open thoracotomy; * American Society of Anesthesiologists (ASA) physical status I to III. Exclusion Criteria: * Pregnancy or lactation; * Urgent or emergency surgeries; * Contraindications to epidural catheter insertion or neuraxial anesthesia; * Infection at the proposed block site; * Patient refusal to undergo the study blocks; * Video-assisted thoracic surgeries; * Anticipated need for invasive mechanical ventilation in the postoperative period; * Chronic opioid use (daily use for more than 3 months of ≥10 mg oral morphine equivalent); * Severe vertebral deformities or previous thoracic spine surgery that prevent safe performance of the blocks; * Known allergy to local anesthetics, opioids, or study medications; * Body mass index \> 35 kg/m²; * Advanced liver or kidney failure (Child-Pugh C or estimated glomerular filtration rate \< 50 mL/min/1.73 m²); * Severe cognitive impairment that prevents understanding of instructions or pain assessment.

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Conditions

The condition(s) this trial relates to.

Acute Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital de Clínicas de Porto Alegre (HCPA)

    Porto Alegre, Rio Grande Do Sul (RS), 90410-000, Brazil

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