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Could a common blood pressure drug be the key to pain-free hemorrhoid recovery?

NCT ID NCT07659665

Symptom relief Sponsor: Sana'a University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 02, 2026 · Updated 3 times

Summary

This study tests whether taking oral nifedipine, a drug usually used for high blood pressure, can reduce pain and improve wound healing after hemorrhoid removal. One hundred adults in Yemen will receive either nifedipine or a placebo twice daily for two weeks after surgery. Researchers will track pain levels, healing progress, and any complications over 28 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nifedipine
What this could lead to
If it works, this could offer a simple, low-cost way to reduce pain and speed recovery after hemorrhoid surgery.
What could go wrong
This is a small, early-phase trial in one country. The drug may not work better than placebo, and side effects like low blood pressure are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged 18-65 years * Scheduled for elective hemorrhoidectomy for grade III or IV hemorrhoids * Ability to provide written informed consent * Ability to understand and complete study questionnaires * Willingness to comply with the study protocol and follow-up visits Exclusion Criteria: * Known hypersensitivity to nifedipine * Severe cardiovascular disease (unstable angina, recent myocardial infarction, severe heart failure) * Hypotension (systolic blood pressure \< 90 mmHg) * Severe hepatic or renal impairment * Pregnancy or breastfeeding * Current use of calcium channel blockers or nitrates * Emergency hemorrhoidectomy * Concurrent inflammatory bowel disease * History of anorectal surgery within the past 6 months

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Conditions

The condition(s) this trial relates to.

agnosia hemorrhoid injury pain agnosia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia Hemorrhoids Postoperative pain Wound healing

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Al-Jumhouri Teaching Hospital

    Sanaa, Yemen

More trials for these conditions

Other studies related to the condition(s) this trial covers.