Postoperative pain

This trial tests whether cocoa husk, a byproduct of chocolate production, can reduce pain and bacteria after root canal treatment. Researchers will compare three approaches in 36 adults with a dead nerve in a lower molar: standard calcium hydroxide, cocoa husk alone, or a mix of …

This trial compares two medications placed inside a tooth after root canal treatment: a hyaluronic acid gel (Hyalone) and the standard calcium hydroxide paste. The goal is to see which one better reduces pain and kills leftover bacteria in infected lower molars. About 28 adults w…

This trial tests whether a simple genetic test can help doctors choose the right painkiller for people recovering from wisdom tooth surgery. Participants are randomly assigned to either standard care or a genetic-guided approach, where their DNA determines if they get tramadol or…

This trial compares two pain management approaches after lumbar spine fusion surgery: standard pain medication alone versus standard care plus a short course of NSAIDs (ketorolac in the hospital and naproxen for a week after discharge). The main question is whether adding NSAIDs …

This study aimed to see if injecting Exparel (a long-acting painkiller) into the vaginal cuff before a minimally invasive hysterectomy could lower pain scores. Participants would have reported pain levels and medication use. However, the trial was withdrawn before any patients en…

This trial tests whether placing tetracycline directly into the tooth socket after removing a lower molar can reduce post-operative pain. About 74 adults needing a molar extraction will be randomly assigned to receive either the antibiotic or no extra treatment. Pain levels will …

This trial tests whether adding the painkiller tramadol to a standard local anesthetic nerve block improves pain control after a mastectomy. Women aged 20-70 scheduled for the surgery will receive either ropivacaine alone or ropivacaine plus tramadol in an ultrasound-guided chest…

This study tests whether a numbing medicine injected around the cervix during vaginal hysterectomy for prolapse can lower pain and reduce the need for strong opioid painkillers afterward. About 56 participants will receive either the numbing medicine or a placebo (saltwater) inje…

This trial compares three common anesthesia techniques—spinal block, inhaled gas, and propofol intravenous anesthesia—for people undergoing robotic-assisted total knee replacement. The goal is to see which approach provides the best pain relief after surgery, reduces the need for…

This trial asks whether bupivacaine or ropivacaine provides better pain relief after thyroid surgery. Adults aged 20-40 scheduled for a total thyroidectomy will receive one of the two anesthetics as a nerve block in the neck. Researchers will measure pain levels, how long until p…

This trial compares two pain medications, tramadol and tapentadol, to see which provides better pain relief after arthroscopic rotator cuff repair surgery. Adults aged 18-80 undergoing this elective shoulder surgery will receive one of the two drugs as part of a multimodal pain m…

This trial tests whether using sodium hypochlorite as a gel or solution, with or without tiny nanoparticles, affects pain after a pulpotomy—a procedure that removes the inflamed pulp inside a tooth. Adults aged 15 to 40 with severe pulpitis in a lower molar will be randomly assig…

This trial tests whether applying cryotherapy (cold therapy) along with different concentrations of sodium hypochlorite irrigation during vital pulp therapy can reduce post-operative pain in permanent mandibular molars. Adults aged 15-40 with symptomatic irreversible pulpitis wil…

This study investigates whether a woman's estrogen levels can predict how much pain she feels after egg retrieval during IVF. Researchers will measure pain scores in 100 women undergoing the procedure with standard anesthesia. The goal is to see if higher estrogen is linked to mo…

This study tests two simple, drug-free methods—vibration and breathing exercises—to see if they can reduce pain and anxiety when a chest tube is removed after surgery. About 70 adults will be randomly assigned to vibration, breathing exercises, or standard care. If effective, the…

This trial tests whether suzetrigine (Journavx), a newly approved non-opioid pain medication, can effectively control pain after thumb basal joint replacement surgery. One hundred adults aged 40 to 80 will receive suzetrigine plus acetaminophen for five days after surgery, and th…

This trial compares five different motion patterns used in root canal treatment to see which one causes the least pain afterward. Adults aged 18 to 65 with asymptomatic root canal needs will be randomly assigned to one of the five motion types. Pain levels and inflammatory marker…

This study tests whether using immersive virtual reality (VR) relaxation right after bariatric surgery can improve recovery. Participants choose calming scenes like mountains or beaches to help them relax. The trial measures how well patients feel they recover, their pain levels,…

This study tests a new medicine called TLC590 for pain after bunionectomy (foot bone surgery). About 300 adults will receive either TLC590, a standard painkiller, or a placebo. The goal is to see if TLC590 reduces pain and the need for opioid painkillers in the first 72 hours aft…

This study tests whether combining two ultrasound-guided pain blocks (M-TAPA and EXOP) works better than M-TAPA alone for controlling pain after laparoscopic gynecologic surgery. About 86 women will have their pain scores, need for extra pain medicine, and recovery quality measur…

This study tests whether an automated pupillometer—a device that measures how the pupil reacts to light—can help doctors better assess and treat pain during and after surgery. 68 adults having abdominal surgery will be randomly assigned to either standard pain care or care guided…

This study tests two different injection spots for a nerve block in the thigh (adductor canal block) to see which provides better pain relief and reduces the risk of falls after total knee replacement. 68 adults having knee surgery under spinal anesthesia will be randomly assigne…

This study tests whether showing children a short educational video before tonsil surgery can lower their fear, anxiety, and pain. Sixty children aged 4 to 10 will watch the video and then have their feelings and pain measured using standard scales. The goal is to find a simple, …

This study compares two types of nerve blocks (serratus plane block and rhomboid intercostal plane block) to see which provides better pain relief after breast reduction surgery. About 90 women will receive one of the blocks before surgery, and their pain and opioid use will be t…

This study tests whether an ultrasound-guided nerve block using bupivacaine can reduce pain after neck surgery better than standard painkillers. Sixty adults aged 18 to 60 undergoing elective neck surgery will be randomly assigned to receive either the nerve block or a placebo in…

This study compares two types of nerve blocks for pain relief during collarbone surgery. The standard block can sometimes cause breathing problems. Researchers are testing a new combination that targets the collarbone area directly, hoping it will provide the same pain relief wit…

This study looks at two types of ultrasound-guided nerve blocks (TAP and QLB) to manage pain after open inguinal hernia repair. 70 adults aged 18-65 will receive one of the blocks before surgery, and their pain levels and need for extra painkillers will be tracked for 24 hours. T…

This study tests whether a single injection of dexamethasone, given right after removing an impacted wisdom tooth, can lower pain over the next three days. Seventy adults aged 20 to 40 are taking part at a dental centre in Lahore. Half get the standard numbing shot, and half get …

This study tests whether a specific nerve block (erector spinae plane block) can lower the need for strong painkillers after open abdominal surgery. About 46 adults having abdominal surgery under general anesthesia will receive the block or standard care. The goal is to see if fe…

This phase 4 trial compares giving no opioids versus a small prescription of 5 opioid tablets after inguinal hernia repair. About 904 adults having elective surgery will be randomly assigned to either group. The main goal is to see if the no-opioid group requests fewer refills wh…

This study tests whether a single injection of dexamethasone, a long-acting steroid, given 30 minutes before wisdom tooth removal can lessen post-surgery pain, facial swelling, and trouble opening the mouth. Sixty adults aged 18 to 35 are randomly assigned to receive either the s…

This study tests whether a specific nerve block (serratus posterior superior intercostal plane block) can reduce pain and the need for painkillers after cervical disc surgery. Forty adults undergoing anterior cervical discectomy will receive either the nerve block plus standard p…

This study looks at whether a specific nerve block (called an erector spinae plane block) can improve pain control after surgery for a slipped disc in the lower back. Researchers will track pain scores, opioid use, how soon patients can walk, and how long they stay in the hospita…

This study tests whether adding two drugs (dexamethasone and dexmedetomidine) to a standard nerve block can extend pain relief after shoulder, foot, or ankle surgery. About 100 adults will be randomly assigned to get either the two-drug combo or dexamethasone alone. The goal is t…

This study tests whether an Enhanced Recovery After Surgery (ERAS) protocol can reduce the need for strong painkillers after a kidney transplant from a living donor. Sixty adult participants will receive a carbohydrate drink, Tylenol, gabapentin, a local numbing injection, and ea…

This study looks at two ways to manage pain after gynecological surgery: the EXORA block and epidural analgesia. Researchers will measure how well each method controls pain and how quickly patients recover their quality of life. The study involves 60 adults aged 18 to 80 who are …

This study compares two types of nerve blocks—M-TAPA and rectus sheath block—for controlling pain after abdominal surgery with a midline cut. Sixty adults will receive one of the two blocks using the same numbing medicine. Researchers will track pain scores and how much extra pai…

This study compares two types of nerve blocks—subcostal TAP block and rectus sheath block—to see which one better controls pain after a large abdominal incision (laparotomy). Sixty adult patients will receive one of the two blocks during surgery, and their pain scores and need fo…

This study aimed to see if taking oral steroids after nose surgery (rhinoplasty) could reduce pain, nausea, swelling, and bruising. It was designed for adults having their first nose surgery, but the study was withdrawn before any participants were enrolled. No results are availa…

This study tests whether a numbing medicine called bupivacaine, injected after nose surgery, can reduce the need for strong opioid pain pills. Fifty adults having septorhinoplasty will receive either the numbing injection or a placebo. Researchers will count how many opioid pills…

This study tests whether adding flurbiprofen axetil to a standard numbing medicine (ropivacaine) injected into the scalp before brain surgery can reduce pain afterward. About 216 adults having brain surgery will be randomly assigned to receive either the combination or the numbin…

This study tests whether a nerve block called serratus intercostal plane block (SIPB) works better than the usual port infiltration for pain after laparoscopic gallbladder removal. 128 adults having this surgery will be randomly assigned to one of the two methods. The goal is to …

This study compares two types of nerve blocks—quadratus lumborum block and retrolaminar block—for pain after lumbar disc surgery. About 84 adults having elective back surgery will receive one of the two blocks before surgery. Researchers will measure pain scores, opioid use, and …

This study planned to compare a minimally invasive version of open hemorrhoidectomy to the standard technique in adults with grade III hemorrhoids. The goal was to see if the newer approach causes less pain after surgery. However, the trial was withdrawn before any participants w…

This study looks at genetic differences in 1,200 children aged 3-15 having tonsillectomy to see if certain genes affect how they respond to morphine. The goal is to predict which children will have serious side effects or poor pain relief. By understanding these genetic links, do…

Researchers at a French hospital are studying whether a national surgical emergency classification system changes patients' quality of life and persistent pain three months after emergency surgery. The study compares patients treated before the system was introduced with those tr…

This study follows 300 adults who receive light therapy before and after plastic surgery as part of their routine care. Researchers will track pain, swelling, bruising, and patient satisfaction over time. The goal is to describe recovery outcomes, not to compare treatments.

This study looks at how the opioid remifentanil changes a person's pain threshold before surgery. Researchers will measure pain using a pressure device on the hand at different drug levels. The goal is to better understand how much opioid is needed, which could help personalize a…

This study looks at whether certain inflammation markers in the blood can predict how well dental numbing shots work and how much pain people feel after treatment. Researchers will analyze blood samples from 150 adults with tooth inflammation (irreversible pulpitis) and compare t…