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Could a dab of antibiotic in the tooth socket dull post-extraction pain?

NCT ID NCT07738861

Symptom relief Sponsor: CMH Lahore Medical College and Institute of Dentistry Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Sep 15, 2026 · Updated 6 times

Summary

This trial tests whether placing tetracycline directly into the tooth socket after removing a lower molar can reduce post-operative pain. About 74 adults needing a molar extraction will be randomly assigned to receive either the antibiotic or no extra treatment. Pain levels will be measured at 24 hours, 48 hours, and 7 days after surgery, along with how many painkillers each person needs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Tetracycline (250 mg) mixed with sterile saline, placed directly into the extraction socket after mandibular molar removal
What this could lead to
If effective, this simple, low-cost approach could become a standard way to ease pain and speed recovery after molar extractions.
What could go wrong
This is a small, early-stage trial, and the benefit may be modest. Tetracycline is an antibiotic, so there is a small risk of allergic reaction or local irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

74 people

The number who actually took part.

Started

Jan 2026

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 60 years. * Male and female participants * Patients requiring surgical extraction of a mandibular molar. * American Society of Anesthesiologists (ASA) Physical Status I or II * Able and willing to provide written informed consent and comply with study follow-up Exclusion Criteria: * Pregnant or lactating women. * Patients with systemic conditions that contraindicate oral surgery (e.g., uncontrolled diabetes mellitus or immunosuppressive disorders). * Current use of antibiotics or medications that may interfere with wound healing (e.g., anticoagulants or bisphosphonates). * Known allergy or hypersensitivity to tetracycline or related antibiotics. * Requirement for simultaneous extraction of adjacent teeth. * Presence of active oral infection, including pericoronitis, at the surgical site. * Severely compromised oral hygiene that may affect postoperative healing. * Individuals who are unable to cooperate with the study procedures or attend follow-up visits because of physical or cognitive impairment.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mandibular molar extraction Postoperative pain Tooth extraction

Contacts and locations

Locations

  • CMH Lahore

    Lahore, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.