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Could a gel ease root canal pain better than standard paste?

NCT ID NCT07775456

Disease control Sponsor: Future University in Egypt Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This trial compares two medications placed inside a tooth after root canal treatment: a hyaluronic acid gel (Hyalone) and the standard calcium hydroxide paste. The goal is to see which one better reduces pain and kills leftover bacteria in infected lower molars. About 28 adults with a dead nerve and painful root tip will receive one of the two treatments. Pain is tracked for a week, and bacterial levels are measured before and after treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Hyaluronic acid gel (Hyalone) compared with calcium hydroxide paste
What this could lead to
If effective, Hyalone could become a gentler alternative to calcium hydroxide for reducing pain and bacteria during root canal treatment.
What could go wrong
This is a small early-stage trial, so results may not apply broadly. Hyalone's effectiveness against deep canal bacteria is unproven, and pain relief may not differ from standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

28 people

The number who actually took part.

Started

Jun 2026

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: Medically free patients with no systemic disease: (American Society of Anesthesiologists / (ASA Class I or II). Positive patient acceptance for participating in the study. Patients able to sign informed consent. Age range is between 20 to 40 years. No sex predilection. Mandibular first molars teeth with necrotic pulp and symptomatic apical periodontitis. Type l distal root canal (Vertucci classification). Teeth Sensitive to percussion. Teeth with Periapical radiographic appearance showing slight widening in lamina dura. Restorable teeth. B- Exclusion criteria: Medically compromised patients. Pregnant or lactating females. Psychologically disturbed patients. Patients with a history of allergy to any medication used in the study were excluded. If anti-inflammatory analgesics or antibiotics have been administrated by patient during the past 12 hours preoperatively. Patients with swelling or acute peri-apical abscess or fistulous tract. Teeth that have: Wide or open apex. Vital pulp tissues. affected with grade 2 or 3 mobility. Not restorable teeth.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bacterial load reduction Postoperative pain

Contacts and locations

Locations

  • Future University In Egypt

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.