Could a gel ease root canal pain better than standard paste?
NCT ID NCT07775456
First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time
Summary
This trial compares two medications placed inside a tooth after root canal treatment: a hyaluronic acid gel (Hyalone) and the standard calcium hydroxide paste. The goal is to see which one better reduces pain and kills leftover bacteria in infected lower molars. About 28 adults with a dead nerve and painful root tip will receive one of the two treatments. Pain is tracked for a week, and bacterial levels are measured before and after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Hyaluronic acid gel (Hyalone) compared with calcium hydroxide paste
- What this could lead to
- If effective, Hyalone could become a gentler alternative to calcium hydroxide for reducing pain and bacteria during root canal treatment.
- What could go wrong
- This is a small early-stage trial, so results may not apply broadly. Hyalone's effectiveness against deep canal bacteria is unproven, and pain relief may not differ from standard care.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Future University In Egypt
Cairo, Egypt
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