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Can genes predict pain relief and opioid risks in kids?

NCT ID NCT01140724

Knowledge-focused Sponsor: Senthil Sadhasivam Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 18, 2026 · Updated 3 times

Summary

This study looks at genetic differences in 1,200 children aged 3-15 having tonsillectomy to see if certain genes affect how they respond to morphine. The goal is to predict which children will have serious side effects or poor pain relief. By understanding these genetic links, doctors may one day personalize pain treatment for children.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors predict which children will have serious side effects from opioids and tailor pain relief to each child.
What could go wrong
This is an observational study, not a treatment trial. It may not lead to immediate changes in care, and genetic predictions may not be accurate for all children.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2022

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Children, 3-15 years of age, undergoing tonsillectomy or adenotonsillectomy at the Riley Hospital for Children, who have consented to participate in an observational clinical study as approved by the IU IRB, protocol # 1707325115.

Ages

3 to 15 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * boys and girls, * 3-15 years of age, * all races, * American Society of Anesthesiologists (ASA) physical status 1,2, and 3, * children with history of significant snoring suggestive of obstructive sleep apnea (OSA), * Scheduled for tonsillectomy (T) or tonsillectomy and adenoidectomy (T and A). Exclusion Criteria: * allergic to study medications * developmental delay, * liver and renal diseases, * preoperative pain requiring analgesics, * children who have problems with pupil or pupillary reaction due to disease * preoperative medications influencing pupillary size * non-English speaking participants and families * Body Mass Index ≥30 * Participants undergoing additional procedures during surgery * Children with certain cardiac conditions * Children with severe lung disease * Children with a history of seizures currently treated on medication * Children with psychiatric/psychological conditions for which patient currently takes medication

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Conditions

The condition(s) this trial relates to.

Pain Pain, Postoperative respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain

Contacts and locations

Locations

  • UPMC Children's Hospital

    Pittsburgh, Pennsylvania, 15224, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.