Senthil Sadhasivam

This study tests a new pain management approach for children aged 10 to 18 having spine surgery for scoliosis. The goal is to see if using methadone as part of a standardized recovery plan can reduce pain and the need for other opioids. The study will enroll 500 participants acro…

This study compares a new methadone-based pain management plan to standard care for 500 children aged 3 to 17 recovering from heart surgery. The goal is to see if the new approach reduces pain and the need for other opioids. Children are randomly assigned to either the new plan o…

This study looks at how opioid use disorder during pregnancy affects both mothers and their babies over time. Researchers will follow 600 pregnant women taking buprenorphine to understand which factors lead to better or worse outcomes, including the baby's risk of withdrawal (neo…

This study aims to create a personalized pain relief plan for women having a C-section. Researchers will look at genetic differences to predict which patients might have bad reactions to opioids, like breathing problems or nausea. The goal is to improve pain control while reducin…

This study aims to create a personalized pain relief plan for children aged 10 to 21 undergoing spine fusion surgery. Researchers will look at specific genes to see how they affect pain relief and side effects from opioids. The goal is to reduce risks like breathing problems and …