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Can the right anesthesia cut Post-Surgery pain and opioid use?

NCT ID NCT04002271

Symptom relief Sponsor: The University of Hong Kong Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial compares three common anesthesia techniques—spinal block, inhaled gas, and propofol intravenous anesthesia—for people undergoing robotic-assisted total knee replacement. The goal is to see which approach provides the best pain relief after surgery, reduces the need for strong painkillers, and supports faster recovery. Participants are randomly assigned to one of the three methods, and their pain levels and medication use are tracked during their hospital stay.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Three anesthesia techniques: spinal anesthesia, general anesthesia with inhaled gas, and general anesthesia with propofol (intravenous).
What this could lead to
If one technique proves superior, it could establish a standard for pain control after robotic knee replacement, reducing opioid use and improving recovery.
What could go wrong
The trial is early and results may not apply to all patients. Each anesthesia method carries inherent risks, and pain outcomes may vary widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Started

Jul 2020

Expected to finish

May 2024

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA I-III * Scheduled for elective primary unilateral total knee replacement * Able to speak and understand Chinese (including Cantonese and Mandarin) * Able to provide informed consent Exclusion Criteria: * Revision total knee replacement * Single stage bilateral total knee replacement * Previous major knee surgery to the same knee * Known allergy to opioids, local anaesthetic drugs, paracetamol, non-steroidal anti-inflammatory drugs (NSAIDS) including COX-2 inhibitors * History of chronic pain other than chronic knee pain * Rheumatoid arthritis * Immunological depression * Chronic opioid user * Alcohol or drug abuse * Obesity (Body mass index over 35kg/m2) * Impaired liver function (Plasma bilirubin over 34 μmol/L, INR ≥ 1.7, ALT and AST over 100U/L) * Impaired renal function, defined as preoperative serum creatinine level over 120 μmol/L * Pre-existing neurological or muscular disorders * Psychiatric or neurological disease that could potentially influencing pain perception * Impaired or retarded mental state * Difficulties in using patient controlled analgesia (PCA) * Pregnancy * Local infection * Patient refusal * Strong preference for a particular type of anaesthesia

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Conditions

The condition(s) this trial relates to.

Acute Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain

Contacts and locations

Locations

  • Queen Mary Hospital

    Hong Kong, Hong Kong

  • The University of Hong Kong

    Hong Kong, Hong Kong

More trials for these conditions

Other studies related to the condition(s) this trial covers.