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Could two drugs together beat one for Post-Surgery pain?

NCT ID NCT07099222

Symptom relief Sponsor: University of Arizona Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding two drugs (dexamethasone and dexmedetomidine) to a standard nerve block can extend pain relief after shoulder, foot, or ankle surgery. About 100 adults will be randomly assigned to get either the two-drug combo or dexamethasone alone. The goal is to see if the combo provides longer pain control and reduces the need for opioid painkillers and their side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexamethasone and dexmedetomidine
What this could lead to
If it works, this could give patients longer-lasting pain relief after surgery with fewer side effects and less need for opioids.
What could go wrong
This is an early-phase trial with only 100 people, so results may not apply to everyone. The combination could also cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy adults (18 years and older but less than 75) * Speaks and understands English. * Capable of performing all activities of daily living independently * Normal development for age and without cognitive impairment * Weight over 50 kg * Undergoing scheduled, elective foot, ankle, and shoulder surgery * Patient is not expected to perform weight-bearing rehabilitation post-op for 1 week. * Regular access to the internet Exclusion Criteria: * Under 18 or older than 75 years of age * Pregnancy * Known allergy to local anesthetics including lidocaine and ropivacaine. * Known allergy to glucocorticoid steroids or necessary abstinence for medical reasons. * Known allergy to dexmedetomidine or other α2 agonist derivatives. * Severe organ dysfunction: end-stage renal disease, liver failure * Severe psychiatric disease that alters sense of reality and interferes with pain perception. * Severe cognitive impairment that interferes with pain perception * Chronic opioid use, alcohol abuse, or any other substance abuse * Urgent/emergent procedure * Emergency return to OR after initial surgery * Infection at block or surgical site * Hemodynamic instability preoperatively * Hemodynamic instability during surgery affects timely extubating at the end of surgery. * Failed nerve blocks that did not end up blocking the nerves as intended, or inadequate nerve blocks requiring repeat rescue blocks in PACU.

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Conditions

The condition(s) this trial relates to.

constipation disorder Dizziness Pain, Postoperative Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Constipation Dizziness Duration of response Narcotics consumption Nausea and vomiting, postoperative Pain after surgery Postoperative pain

Contacts and locations

Locations

  • Banner - University Medical Center South

    Tucson, Arizona, 85713, United States

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