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Blood markers may predict why your dental numbing fails

NCT ID NCT07163065

Knowledge-focused Sponsor: KEZBAN MELTEM ÇOLAK Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at whether certain inflammation markers in the blood can predict how well dental numbing shots work and how much pain people feel after treatment. Researchers will analyze blood samples from 150 adults with tooth inflammation (irreversible pulpitis) and compare them to anesthesia success and post-op pain. The goal is to help dentists identify patients who may need extra numbing or pain relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help dentists predict which patients might have a failed numbing shot and improve pain management for dental procedures.
What could go wrong
This is an observational study, not a treatment trial. It only looks for links between blood markers and anesthesia success, so it won't directly change care yet.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Oct 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients (18-65 years) requiring mandibular dental treatment under inferior alveolar nerve block anesthesia at Atatürk University Faculty of Dentistry, Department of Endodontics.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged between 18 and 65 years. Patients with a pain score greater than 54 on the Heft-Parker Visual Analog Scale (VAS). Patients classified as ASA I according to the American Society of Anesthesiologists (ASA). Teeth with probing depths less than 3 mm, suitable for rubber dam placement and restoration. Vital mandibular molar teeth with a clinical diagnosis of irreversible pulpitis, confirmed by pulp vitality tests (electric pulp testing and cold testing). Presence of bleeding upon access to the pulp chamber. No use of non-steroidal anti-inflammatory drugs (NSAIDs) within the last 12 hours. Absence of allergy to articaine. Patient's consent to provide a blood sample. Exclusion Criteria: * Patients classified as ASA II or higher. Pregnant women or those with suspected pregnancy. Patients with periodontal pockets greater than 3 mm in the involved tooth. Patients who received treatment with NSAIDs within the last 12 hours. Patients allergic to articaine. Teeth that had undergone previous endodontic treatment. Teeth with extensive structural loss preventing rubber dam isolation. Presence of internal or external root resorption.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental anesthesia complications Inferior alveolar nerve block failure Inflammation biomarkers Postoperative pain

Contacts and locations

Locations

  • Atatürk University Faculty of Dentistry, Department of Endodontics

    Erzurum, Erzurum, 25240, Turkey (Türkiye)

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