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No pain pills? study tests Opioid-Free recovery after hernia repair

NCT ID NCT05929937

Symptom relief Sponsor: Clayton Petro Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 4 trial compares giving no opioids versus a small prescription of 5 opioid tablets after inguinal hernia repair. About 904 adults having elective surgery will be randomly assigned to either group. The main goal is to see if the no-opioid group requests fewer refills while still managing pain and quality of life equally well.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Opioids (Oxycodone 5mg tablets)
What this could lead to
If successful, this could show that many hernia repair patients can manage pain without opioids, reducing the risk of opioid dependence.
What could go wrong
This is a single study on a specific surgery type, so results may not apply to other procedures. Some patients may still need opioids for adequate pain relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 904 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2023

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged 18 years or older * Patients undergoing elective unilateral or bilateral inguinal hernia repairs * Patients able to tolerate general anesthesia Exclusion Criteria: * Patients who cannot tolerate general anesthesia, * Patients who cannot tolerate opioids or NSAIDS, * Patients on opioids for chronic pain management (defined as near daily use within 90 days), * Patients who undergo surgeries requiring extensive dissection/hernia sac reduction, or additional procedures, * Patients requiring inpatient admission postoperatively * Patients who are not able to understand and sign a written consent form

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Conditions

The condition(s) this trial relates to.

Hernia, Inguinal Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inguinal hernia Postoperative pain

Contacts and locations

Locations

  • Cleveland Clinic Center for Abdominal Core Health

    Cleveland, Ohio, 44195, United States

  • Corewell Health

    Royal Oak, Michigan, 48073, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • MemorialCare

    Fountain Valley, California, 92708, United States

  • North York General Hospital

    Toronto, Ontario, Canada

  • Prisma Health

    Greenville, South Carolina, 29607, United States

  • University Hospitals

    Cleveland, Ohio, 44106, United States

  • University of Tennessee Medical Center

    Knoxville, Tennessee, 37920, United States

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