No pain pills? study tests Opioid-Free recovery after hernia repair
NCT ID NCT05929937
First seen Nov 11, 2025 · Last updated Jun 20, 2026 · Updated 26 times
Summary
This phase 4 trial compares giving no opioids versus a small prescription of 5 opioid tablets after inguinal hernia repair. About 904 adults having elective surgery will be randomly assigned to either group. The main goal is to see if the no-opioid group requests fewer refills while still managing pain and quality of life equally well.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Cleveland Clinic Center for Abdominal Core Health
Cleveland, Ohio, 44195, United States
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Corewell Health
Royal Oak, Michigan, 48073, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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MemorialCare
Fountain Valley, California, 92708, United States
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North York General Hospital
Toronto, Ontario, Canada
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Prisma Health
Greenville, South Carolina, 29607, United States
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University Hospitals
Cleveland, Ohio, 44106, United States
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University of Tennessee Medical Center
Knoxville, Tennessee, 37920, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Opioids (Oxycodone 5mg tablets)
What this could lead to
If successful, this could show that many hernia repair patients can manage pain without opioids, reducing the risk of opioid dependence.
What could go wrong
This is a single study on a specific surgery type, so results may not apply to other procedures. Some patients may still need opioids for adequate pain relief.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.