No pain pills? study tests Opioid-Free recovery after hernia repair

NCT ID NCT05929937

Ongoing Symptom relief Sponsor: Clayton Petro Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 4 trial compares giving no opioids versus a small prescription of 5 opioid tablets after inguinal hernia repair. About 904 adults having elective surgery will be randomly assigned to either group. The main goal is to see if the no-opioid group requests fewer refills while still managing pain and quality of life equally well.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Opioids (Oxycodone 5mg tablets)
What this could lead to: If successful, this could show that many hernia repair patients can manage pain without opioids, reducing the risk of opioid dependence.
What could go wrong: This is a single study on a specific surgery type, so results may not apply to other procedures. Some patients may still need opioids for adequate pain relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hernia, Inguinal Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INGUINAL HERNIA POSTOPERATIVE PAIN

Contacts and locations

Locations

Cleveland Clinic Center for Abdominal Core Health

Cleveland, Ohio, 44195, United States
Corewell Health

Royal Oak, Michigan, 48073, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
MemorialCare

Fountain Valley, California, 92708, United States
North York General Hospital

Toronto, Ontario, Canada
Prisma Health

Greenville, South Carolina, 29607, United States
University Hospitals

Cleveland, Ohio, 44106, United States
University of Tennessee Medical Center

Knoxville, Tennessee, 37920, United States

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