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One shot before wisdom tooth pull may cut pain and lockjaw

NCT ID NCT07554963

Symptom relief Sponsor: Hayat Abad Medical Complex, Peshawar Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a single 4 mg dose of dexamethasone, given as a shot under the gum before surgery, can reduce pain and difficulty opening the mouth after impacted lower wisdom tooth removal. 268 adults aged 18 to 55 will be randomly assigned to receive the steroid or standard care alone. Pain and mouth opening will be measured on days 2 and 7 after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexamethasone
What this could lead to
If it works, this could provide a simple, low-cost way to reduce pain and jaw stiffness after wisdom tooth removal.
What could go wrong
This is a small, early-phase trial. The benefit may be small or not apply to everyone. Dexamethasone can have side effects like delayed healing or infection risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 268 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 55 years * Patients requiring surgical extraction of impacted mandibular third molars * Patients willing to provide informed consent Exclusion Criteria: * Patients with systemic diseases * Patients with periodontal disease * Pregnant or lactating women * Patients who have used antibiotics or anti-inflammatory drugs within the past 7 days * Patients with known hypersensitivity to dexamethasone

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative Tooth, Impacted Trismus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impacted mandibular third molar Postoperative pain Trismus

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.