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New nerve block could replace morphine for hip surgery pain

NCT ID NCT07449585

Symptom relief Sponsor: Medical University of Gdansk Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares a nerve block (PENG) to spinal morphine for pain after total hip replacement. About 180 adults will be randomly assigned to one of three groups: PENG block, spinal morphine, or spinal anesthesia alone. The goal is to see which method provides better pain control with fewer side effects like nausea and itching.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ropivacaine and dexamethasone (PENG block) vs. morphine (intrathecal)
What this could lead to
If the PENG block works better, it could offer a safer way to manage pain after hip replacement, reducing the need for opioids and their side effects.
What could go wrong
This is a small, early-stage trial that hasn't started yet. The nerve block may not be as effective as morphine, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 180 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Informed, written consent for study participation. * Qualification for elective primary total hip arthroplasty via a posterolateral approach. * Age above 18 years. * ASA Physical Status I-III. * Absence of contraindications to spinal anesthesia. * Absence of contraindications to performing a Pericapsular Nerve Group (PENG) block. * Absence of contraindications to the administration of the pharmacological agents utilized in the study. Exclusion Criteria: * Absence of informed consent. * Age below 18 years. * Psychoactive substance abuse or dependence. * Chronic opioid therapy. * Contraindications to spinal anesthesia. * Contraindications to the Pericapsular Nerve Group (PENG) block. * Contraindications to the administration of study medications. * Body Mass Index (BMI) above 30 kg/m\^2. * Pregnancy. * History of chronic pain management.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hip disease Hip replacement, total Perioperative analgesia Postoperative pain

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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