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Pre-surgery ibuprofen may shield elderly brains from post-op fog

NCT ID NCT07424001

Symptom relief Sponsor: Mehmet Çiğdem Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving ibuprofen before hernia surgery helps older adults avoid confusion and memory problems after the operation. Seventy-six men aged 65-84 received either ibuprofen or a placebo before surgery. Researchers measured their thinking skills, pain levels, and recovery quality for a week after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ibuprofen
What this could lead to
If it works, this could point toward a simple way to protect older patients' thinking and memory after surgery.
What could go wrong
This is a small, early-phase study in only 76 men, so results may not apply to everyone. Ibuprofen can cause stomach or kidney problems in some people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

76 people

The number who actually took part.

Started

Sep 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 84 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male patients between the ages of 65 and 84. * ASA (American Society of Anesthesiologists) physical status I - III. * Preoperative Mini-Mental State Examination (MMSE) score of \\ge24. * Undergoing elective (non-emergency) open inguinal hernia repair using the * Lichtenstein tension-free method with mesh. * Literate and able to communicate sufficiently to understand Turkish cognitive tests. Exclusion Criteria: * Illiterate patients. * History of active alcoholism or substance abuse. * Neuro-psychiatric disorders such as Parkinson's, Alzheimer's, vascular dementia, advanced stroke sequelae, schizophrenia, or major depressive disorder. * Active metastatic cancer or terminal illness. * Known allergy to nonsteroidal anti-inflammatory drugs (especially ibuprofen), acetylsalicylic acid, or other drugs used in the study. * Advanced COPD or uncontrolled bronchial asthma (FEV1 \<50%). * Uncontrolled hypertension, congestive heart failure (NYHA Class IV), recent myocardial infarction, or serious arrhythmias. * Thrombocytopenia (\<50,000), coagulopathy, active peptic ulcer, or recent gastrointestinal bleeding history (within the last year). * Advanced liver failure (Child-Pugh C) or kidney failure (creatinine \>2.5 mg/dL or dialysis requirement). * Body Mass Index (BMI) \\ge35 (morbid obesity) or body weight \<40 kg.

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Conditions

The condition(s) this trial relates to.

Neuroinflammatory Diseases neuronitis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Delayed neurocognitive recovery Inguinal hernia unilateral Neuroinflammation Postoperative pain Preemptive analgesia

Contacts and locations

Locations

  • Istanbul medeniyet Universitesi Prof. Dr. Süleyman Yalçın Şehir Hastanesi

    Istanbul, Kadıköy, 34710, Turkey (Türkiye)

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