Pre-surgery ibuprofen may shield elderly brains from post-op fog

NCT ID NCT07424001

Completed Symptom relief Sponsor: Mehmet Çiğdem Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving ibuprofen before hernia surgery helps older adults avoid confusion and memory problems after the operation. Seventy-six men aged 65-84 received either ibuprofen or a placebo before surgery. Researchers measured their thinking skills, pain levels, and recovery quality for a week after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ibuprofen
What this could lead to: If it works, this could point toward a simple way to protect older patients' thinking and memory after surgery.
What could go wrong: This is a small, early-phase study in only 76 men, so results may not apply to everyone. Ibuprofen can cause stomach or kidney problems in some people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Neuroinflammatory Diseases neuronitis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DELAYED NEUROCOGNITIVE RECOVERY INGUINAL HERNIA UNILATERAL NEUROINFLAMMATION POSTOPERATIVE PAIN PREEMPTIVE ANALGESIA

Contacts and locations

Locations

Istanbul medeniyet Universitesi Prof. Dr. Süleyman Yalçın Şehir Hastanesi

Istanbul, Kadıköy, 34710, Turkey (Türkiye)

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