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Blood clot trick may cut wisdom tooth pain

NCT ID NCT07604584

Symptom relief Sponsor: Ankara University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a substance made from a patient's own blood, called platelet-rich fibrin (PRF), could reduce pain, swelling, and jaw stiffness after impacted wisdom tooth surgery. Thirty smokers and nonsmokers each had one tooth socket treated with PRF and the other left as a control. Researchers measured pain, swelling, and mouth opening during the first week after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
platelet-rich fibrin (PRF)
What this could lead to
If it works, this could offer a simple, natural way to reduce pain and speed recovery after wisdom tooth surgery, especially for smokers.
What could go wrong
This is a small, completed study with only 30 people. Results may not apply to everyone, and PRF may not work better than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

May 2017

Finished

Dec 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy patients aged between 18 and 35 years * Bilaterally impacted mandibular third molars * Mandibular third molars classified as Pell and Gregory Class I, Position C * Mandibular third molars classified as Parant Class II difficulty * Smoking and nonsmoking patients * Patients willing to participate and provide written informed consent Exclusion Criteria: * Presence of acute infection or pericoronitis * Pregnancy or lactation * Alcohol or substance abuse * Use of oral contraceptives * Menstrual period during surgery * Antibiotic use within the previous month * Smoking more than 10 cigarettes per day * Agitation or inability to cooperate * Incomplete follow-up data * Systemic disease contraindicating oral surgery

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative Smoking Trismus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Facial swelling Impacted mandibular third molar Postoperative pain Trismus

Contacts and locations

Locations

  • Ankara University Faculty of Dentistry

    Ankara, 06560, Turkey (Türkiye)

More trials for these conditions

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