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Brain surgery anesthesia showdown: which method causes less confusion?

NCT ID NCT07357480

Knowledge-focused Sponsor: Istanbul University - Cerrahpasa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 10, 2026 · Updated 3 times

Summary

This study compares two ways of giving anesthesia during brain surgery: a computer-controlled pump versus manual control by the anesthesiologist. The goal is to see which method leads to less postoperative delirium (confusion), pain, and nausea. Researchers will study 70 adults having elective brain surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
propofol and remifentanil
What this could lead to
If it works, this could point toward a better way to give anesthesia during brain surgery, potentially reducing confusion and pain after the operation.
What could go wrong
This is a small, early-stage study with only 70 people, so results may not apply to everyone. It compares two techniques but does not test a new drug or cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

63 people

The number who actually took part.

Started

Jan 2026

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged 18 to 60 years * Scheduled for elective supratentorial surgery under general anesthesia * American Society of Anesthesiologists (ASA) physical status I or II * Planned total intravenous anesthesia with propofol and remifentanil * Ability to provide written informed consent Exclusion Criteria: * Refusal or inability to provide written informed consent * American Society of Anesthesiologists (ASA) physical status III or higher * Pregnancy * Emergency surgery * Presence of brain herniation * Anticipated or documented difficult airway * Inability to communicate effectively (e.g., non-Turkish speaking or hearing impairment) * Preoperative risk factors for delirium, including substance abuse, use of neuropsychiatric medications, preoperative hemoglobin level \< 8 g/dL, malnutrition, or electrolyte or thyroid hormone abnormalities * Intraoperative deviation from the study protocol, including changes in surgical or anesthetic technique or occurrence of major intraoperative complications * Contraindications to propofol or remifentanil

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Conditions

The condition(s) this trial relates to.

Emergence Delirium Pain, Postoperative Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Burst suppression PONV Postoperative delirium (POD) Postoperative pain Recovery period, anesthesia

Contacts and locations

Locations

  • Cerrahpaşa Tıp Fakültesi Murat Dilmener Hastanesi

    Istanbul, Istanbul, 34153, Turkey (Türkiye)

  • Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine

    Istanbul, Bakırköy, 34153, Turkey (Türkiye)

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