Postoperative delirium (POD)

This trial investigates whether maintaining a higher blood pressure (85 mmHg or above) during surgery can reduce the risk of postoperative delirium—a sudden confusion that can occur after surgery—in older adults (65+) with high blood pressure. About 3,400 participants having non-…

This study compares two drug combinations—ketofol (ketamine plus propofol) and ketodex (ketamine plus dexmedetomidine)—to see which better prevents postoperative delirium in patients 60 and older undergoing open cancer surgery in the pelvis or abdomen. Delirium is a common, serio…

This study tracks 230 adults having planned heart surgery to see if unstable blood pressure during the operation raises the risk of serious problems like confusion, kidney injury, stroke, or death within 30 days. Researchers will monitor blood pressure dips and use of pressure-ra…

This study follows 130 adults undergoing surgery for stomach or esophageal cancer to see how often they experience postoperative delirium—a state of confusion and disorientation after anesthesia. Researchers will also check whether depression, frailty, poor nutrition, or muscle l…

This study looks at whether older women are more likely than men to develop confusion after surgery (postoperative delirium) and whether family visits play a role. Researchers will follow 471 patients aged 65 and older having non-cardiac surgery. No new treatments are tested—just…

This study is watching 1,200 older adults (65+) before, during, and after surgery to learn why some get complications like confusion (delirium). Researchers will collect blood samples and health information to build a tool that predicts these risks. The goal is to better understa…

This study looks at whether a backup of blood in the veins during heart surgery is linked to confusion (delirium) after the operation. Researchers will monitor 120 adults having planned heart surgery. The goal is to understand this possible connection, not to test a new treatment…