Postoperative delirium (POD)

This study tests whether a step-by-step plan to manage body temperature during a long surgery can lower the chance of postoperative delirium (sudden confusion). The surgery is for a rare abdominal tumor called pseudomyxoma peritonei and involves heated chemotherapy. The trial wil…

This trial asks whether giving the painkiller dezocine before and after heart surgery can reduce the chance of postoperative delirium—a state of confusion that commonly affects older patients after cardiac procedures. Researchers plan to enroll 640 adults aged 65 and older who ar…

This study tests whether practicing deep breathing exercises before surgery can lower the chance of postoperative delirium—a state of confusion and disorientation—in men undergoing robot-assisted prostate removal for prostate cancer. Half of the 50 participants will be taught a s…

This trial investigates whether a nasal spray containing insulin can prevent postoperative delirium—a sudden, temporary state of confusion—in older adults (65+) with type 2 diabetes who are undergoing liver tumor surgery. Participants are randomly assigned to receive one of two d…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can prevent postoperative delirium in elderly patients undergoing urological surgery. Researchers will apply TMS to the left frontal lobe during anesthesia and monit…

Aortic arch surgery temporarily cuts blood flow to the brain, which can leave patients with lasting thinking and memory problems. Researchers at Seoul National University Hospital are testing whether anesthesia with remimazolam, rather than propofol, lowers the chance of that cog…

This trial tests whether wearing a light-blocking eye mask at night can improve sleep quality and reduce delirium in patients recovering from coronary artery bypass graft (CABG) surgery. About 100 adults scheduled for elective CABG will wear the mask during nighttime sleep, and t…

This study tests whether a nasal spray containing dexmedetomidine can reduce the chance of postoperative delirium (sudden confusion) in people 65 and older after lung surgery. About 264 participants will be randomly assigned to get either the drug or a placebo spray before surger…

This study tests whether a nasal spray called dexmedetomidine, taken at night, can help older adults (ages 65-90) sleep and reduce the risk of delirium after major abdominal surgery. 400 participants will be randomly assigned to receive either the drug or a placebo. The goal is t…

This study tests a device that gently stimulates a nerve in the ear during heart surgery. The goal is to see if it lowers the chance of postoperative delirium, anxiety, and depression. About 270 adults having elective heart surgery will be randomly assigned to receive real or sha…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study looks at whether changes in heart rate variability (HRV) shortly after major abdominal surgery can help predict postoperative delirium—a state of confusion that can affect older patients. Researchers will measure HRV in 500 adults aged 65-85 before and within 24 hours …

This study will collect blood, urine, stool, voice recordings, and other data from 3000 adults having planned heart surgery. Researchers will analyze this information to find markers that could predict complications like delirium, bleeding, kidney injury, and irregular heartbeat.…