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Can a painkiller shield older hearts from Post-Surgery confusion?

NCT ID NCT07768150

Prevention Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time

Summary

This trial asks whether giving the painkiller dezocine before and after heart surgery can reduce the chance of postoperative delirium—a state of confusion that commonly affects older patients after cardiac procedures. Researchers plan to enroll 640 adults aged 65 and older who are scheduled for heart surgery using a heart-lung machine. Half will receive dezocine, and half will receive a placebo (saline), with the main goal of comparing how many in each group develop delirium within a week after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dezocine (an opioid painkiller) given intravenously before and after heart surgery
What this could lead to
If effective, dezocine could become a simple preventive treatment to lower the risk of confusion and delirium after heart surgery in older adults.
What could go wrong
This is an early-stage trial, and the results may not show a clear benefit. Dezocine, like other opioids, can have side effects such as drowsiness or nausea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 640 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥65 years. 2. Patients scheduled for elective cardiac surgery requiring cardiopulmonary bypass. 3. Ability to complete preoperative cognitive assessment. 4. Written informed consent provided by the patient or legally authorized representative. Exclusion Criteria: 1. Pre-existing neurological or psychiatric disorders that may affect postoperative delirium assessment, including dementia, active delirium, severe psychiatric disorders, recent stroke, or other severe neurological diseases. 2. Severe visual or hearing impairment or other conditions preventing postoperative delirium assessment. 3. Long-term use of opioid analgesics or sedative-hypnotic medications, or known allergy to dezocine. 4. Severe hepatic or renal dysfunction. 5. Emergency surgery, redo sternotomy, aortic surgery, or complex combined cardiac surgery.

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Conditions

The condition(s) this trial relates to.

Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative delirium (POD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fuwai Hospital, Chinese Academy of Medical Sciences

    Beijing, Beijing Municipality, 100037, China

  • Fuwai Hospital, Chinese Academy of Medical Sciences

    Beijing, China

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