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Common painkiller ibuprofen put to the test after joint surgery

NCT ID NCT05575700

Disease control Sponsor: Naestved Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Over 2,900 adults were randomly given either ibuprofen or a placebo. Researchers tracked serious problems like heart attack, stroke, blood clots, kidney failure, and bleeding for 90 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ibuprofen
What this could lead to
If ibuprofen is found safe, it could confirm a common painkiller as a standard option after joint replacement surgery.
What could go wrong
This is a completed Phase 4 trial, but results are not yet published. Ibuprofen can still cause stomach ulcers, kidney problems, or bleeding in some people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

2,904 people

The number who actually took part.

Started

Apr 2023

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled for elective primary hip and knee arthroplasty. * Age ≥ 18 years. * Planned postoperative treatment with NSAID. * Negative pregnancy test for women in the fertile age. * Informed consent. Exclusion Criteria: * Unable to understand or speak Danish. * Allergy to or contraindications against ibuprofen.

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Conditions

The condition(s) this trial relates to.

Acute Pain agnosia arthropathy osteoarthritis, hip osteoarthritis, knee pain agnosia Pain, Postoperative Postoperative Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia Analgesic adverse reaction Hip arthropathy Knee arthropathy Pain, acute Postoperative complications Postoperative pain Safety issues

Contacts and locations

Locations

  • Aalborg University Hospital

    Farsø, 9640, Denmark

  • Bispebjerg Hospital

    Copenhagen NV, 2400, Denmark

  • Gentofte Hospital

    Hellerup, 2900, Denmark

  • Nordsjællands Hospital Hillerød

    Hillerød, 3400, Denmark

  • Næstved Hospital

    Næstved, 4700, Denmark

  • Odense University Hospital

    Odense, 3900, Denmark

  • Private Hospital Gildhøj

    Brøndby, 2605, Denmark

  • Silkeborg Regional Hospital

    Silkeborg, 8600, Denmark

  • Svendborg Hospital

    Svendborg, 5700, Denmark

  • Vejle Sygehus

    Vejle, 7100, Denmark

  • Zealand University Hospital

    Køge, 4600, Denmark

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