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Vitamin c shot may boost pain relief after knee surgery

NCT ID NCT05514197

Symptom relief Sponsor: Chimei Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether giving a single high dose of vitamin C through an IV, along with nerve blocks, could reduce pain and help people recover faster after total knee replacement. 73 adults aged 50 to 80 took part. The researchers measured pain levels, soreness, and how much morphine was needed after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vitamin C (ascorbic acid)
What this could lead to
If it works, this could offer a simple, low-cost way to improve pain control and recovery after knee replacement surgery.
What could go wrong
This is a small, completed trial with only 73 participants, so results may not apply to everyone. High-dose vitamin C can cause side effects like nausea or kidney stones in some people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

73 people

The number who actually took part.

Started

Nov 2022

Finished

Jan 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Physical status according to American Society of Anesthesiologists (ASA) I-III 2. Patients scheduled for total knee arthroplasty 3. Patients aged ranging from 50 to 80 years old Exclusion Criteria: 1. Previous operation on the same knee 2. Allergy or intolerance to one of the study medications 3. Coagulopathy 4. Having lower limbs neuropathy 5. End-organ failure (CKD stage IV or V, NYHA III or IV) 6. BMI \> 35 7. Chronic opioid use (\>3 months) or drug abuser 8. Difficulty in communication (Impaired mental status) 9. Hyperuricemia or Glucose-6-phosphate dehydrogenase deficiency patient

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Conditions

The condition(s) this trial relates to.

osteoarthritis Pain, Postoperative scurvy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ascorbic acid Postoperative pain

Contacts and locations

Locations

  • Chi Mei Medical Center

    Tainan, Tainan City, 701, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.