Could a simple drug combo cut opioid use after lung surgery?

NCT ID NCT07359469

Knowledge-focused Sponsor: Universidad Pública de Navarra Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study examined whether giving lidocaine, ketamine, and magnesium during lung surgery helps reduce pain and the need for morphine afterward. Researchers followed 118 adults who had lung surgery and recorded their pain levels and opioid use. The goal was to see if this drug combination, already used in some hospitals, improves recovery without extra risks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: lidocaine, ketamine, and magnesium (intravenous)
What this could lead to: If the results are positive, this could point toward a standard way to reduce pain and opioid use after lung surgery.
What could go wrong: This was an observational study, not a controlled trial, so it cannot prove cause and effect. The findings may not apply to all patients or surgical settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

118 people

The number who actually took part.

Started

Jan 2018

Finished

May 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients undergoing elective pulmonary resection (thoracotomy or video-assisted thoracoscopic surgery) at University Hospital Dr. Josep Trueta. The study population includes individuals receiving standard perioperative analgesic management and monitored in the postoperative care unit. Patients represent a typical thoracic surgery clinical population treated in routine practice.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. * Scheduled for elective pulmonary resection (thoracotomy or VATS). * Able to provide informed consent. * ASA physical status I-IV. Exclusion Criteria: * Emergency surgery. * Known allergy or contraindication to lidocaine, ketamine, or magnesium. * Severe hepatic insufficiency. * Severe renal dysfunction (eGFR \< 30 mL/min/1.73 m²). * Pre-existing significant arrhythmias (e.g., uncontrolled atrial fibrillation, ventricular arrhythmias). * Pregnancy. * Cognitive impairment preventing valid informed consent. * Patients receiving chronic intravenous analgesics or regional anesthesia techniques preoperatively.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multimodal analgesia Opioid consumption, postoperative Postoperative pain Thoracic surgery

Could a simple drug combo cut opioid use after lung surgery?

What the study statuses mean