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New root canal gel may ease pain between dental visits

NCT ID NCT07396688

Symptom relief Sponsor: Ankara University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 3 times

Summary

This study tests whether a newer root canal medication called Bio-C Temp causes less pain between dental visits than the standard calcium hydroxide. Sixty adults needing root canal retreatment will receive one of the two medications. Their pain levels and painkiller use will be tracked to see which option is more comfortable.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
calcium hydroxide or bioceramic-based intracanal medicament (Bio-C Temp)
What this could lead to
If it works, this could help dentists choose a medication that reduces pain between root canal visits, improving patient comfort.
What could go wrong
This is a small, early-stage study with only 60 people, so results may not apply to everyone. Pain is subjective and hard to measure precisely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Sep 2025

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Patients with single-rooted teeth requiring endodontic retreatment. * Individuals in good general health, classified as ASA Physical Status I. * Teeth presenting normal anatomical structure and root morphology. Exclusion Criteria: * • Patients who have used antibiotics or analgesic medications within the last month. * Pregnant individuals and patients with systemic diseases (such as chronic illnesses, diabetes mellitus, hypertension). * Teeth with root fractures or perforations. * Teeth with complex root canal anatomy, multirooted teeth, or severely curved roots. * Patients presenting with high baseline pain levels, particularly those with a history of treatment-resistant pain.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Calcium hydroxide Medicaments substances in therapeutic use Postoperative pain Root canal retreatment

Contacts and locations

Locations

  • Ankara University Faculty of Dentistry

    Ankara, Ankara, 06100, Turkey (Türkiye)

  • Ankara University Faculty of Dentistry

    Ankara, Ankara, 06500, Turkey (Türkiye)

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