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Knee replacement patients: when the nerve block wears off, severe pain may return

NCT ID NCT06966011

Knowledge-focused Sponsor: Konya City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed 294 knee replacement patients to see how often they experienced sudden, severe pain after their nerve block wore off. Researchers tracked pain levels, sleep quality, and patient satisfaction. The goal was to better understand this 'rebound pain' and improve pain management after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

294 people

The number who actually took part.

Started

May 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients aged 18 to 70 years who are scheduled for elective unilateral total knee arthroplasty under spinal anesthesia at a tertiary care hospital. All participants will receive peripheral nerve blocks as part of a standardized multimodal analgesia protocol. Patients must be physically and cognitively able to provide consent and complete a postoperative pain diary. Those with contraindications to regional anesthesia, allergies to local anesthetics, or significant comorbidities (ASA IV and above) will be excluded.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 70 years * ASA physical status I to III * Scheduled for elective unilateral total knee arthroplasty under spinal anesthesia * Peripheral nerve block (PNB) planned as part of multimodal analgesia * Ability to understand and provide written informed consent * Willingness and ability to complete the postoperative pain diary Exclusion Criteria: * Known allergy or hypersensitivity to local anesthetics * Contraindication to regional anesthesia * ASA physical status IV or higher * Neurological or psychiatric disorders interfering with study participation or pain reporting * Use of anticoagulants or presence of coagulopathy * Use of medications that may alter pain perception or rebound pain response * Local infection at the block site * Emergency surgeries * Inability or unwillingness to complete the postoperative pain diary or follow-up

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Conditions

The condition(s) this trial relates to.

agnosia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain management Peripheral nerve block Postoperative pain Rebound pain Total knee arthroplasty

Contacts and locations

Locations

  • Konya City Hospital

    Konya, 42090, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.