TOTAL KNEE ARTHROPLASTY

This study is testing a new computer navigation system called NextAR. It helps surgeons position a new knee implant to better match a patient's natural knee movement and ligament tension. Researchers will compare outcomes for 100 patients getting a total knee replacement, with ha…

This study is comparing two methods for attaching a robotic-assisted knee replacement implant: using surgical bone cement versus a cementless design that allows bone to grow into the implant. It aims to find out which method leads to a more natural-feeling, longer-lasting knee fo…

This study is testing whether antioxidant supplements given around the time of knee replacement surgery can prevent long-term chronic pain. Researchers will enroll 148 adults aged 50+ with osteoarthritis who are scheduled for knee replacement. Participants will receive either the…

This study is testing which of three methods for delivering an antibiotic (vancomycin) is most effective at preventing serious infections after knee replacement surgery. Researchers are comparing injections directly into the joint, into the bone, or through an IV. The goal is to …

This study is testing whether adding a specific type of electrical muscle stimulation to standard physical therapy helps people recover better after knee replacement surgery. It will involve about 3,250 patients across 30 clinics, comparing those who get the stimulation treatment…

This study is testing a new computer tool designed to help physical therapists create more personalized rehabilitation plans for veterans recovering from total knee replacement surgery. Instead of giving everyone the same therapy, the tool uses data to predict an individual's rec…

This study is testing two different methods for managing pain after total knee replacement surgery. Researchers want to see if using a small, temporary catheter that continuously delivers numbing medicine to the leg for about two days works better than a standard single injection…

This study compares three different nerve-blocking techniques to control pain after total knee replacement surgery. Researchers want to find which method provides the most effective pain relief while allowing patients to move their leg sooner for faster recovery. The trial will i…

This study is testing if a special virtual reality education session before knee replacement surgery can help reduce patients' fear of the operation and their fear of moving afterward. About 48 patients will be randomly assigned to either get this new VR education or the standard…

This study is testing whether using noise-canceling headphones with music or a movie can help patients need less sedation medication during knee replacement surgery. Researchers will compare patients who use the headphones to those who don't to see if it reduces the amount of sed…

This study is testing whether adding whole-body vibration therapy to standard rehab helps women with low bone density recover better after knee replacement surgery. Researchers will compare vibration alone, vibration with exercise, and standard rehab to see which best improves st…

This study is testing whether a new drug called BT-114143 can safely reduce blood loss during and after knee replacement surgery. It will compare two different doses of the new drug against a standard medication (tranexamic acid) in 270 adults having the surgery. The main goal is…

This study aims to find the best way to manage pain after knee replacement surgery. Researchers are comparing two different nerve block techniques (iPACK and BiFeS) when used with a standard pain control method. The goal is to see which combination provides better pain relief, im…

This small study is testing if using a special walking bike, called the Alinker, can help people move around better and with less pain after total knee replacement surgery. Participants will use the bike before and for three months after their operation. Researchers will track ho…

This study is testing a new way to manage pain after knee replacement surgery. It compares a new surgeon-administered injection inside the knee joint against two standard pain control methods. The goal is to see which approach provides better pain relief, reduces the need for ext…

This study aims to find the best dose of a long-acting numbing medicine (liposomal bupivacaine) given as a nerve block to control pain after knee replacement surgery. Researchers will compare how well different doses reduce pain and the need for opioid painkillers in 177 adults u…

This study is testing if a specific eating and drinking plan before knee replacement surgery helps patients feel better afterward. Researchers want to see if this plan reduces thirst, nausea, and vomiting in the first two days after surgery. They will compare patients who follow …

This study aims to understand how remote monitoring devices and neighborhood resources affect recovery after knee replacement surgery. Researchers will track 150 patients using smart knee implants that measure movement and compare their recovery to patients receiving standard car…

This study aims to see if data from smart shoe insoles and other pre-surgery information can predict how well patients will recover after a total knee replacement. Researchers will observe 200 patients, analyzing their walking patterns before surgery and their reported pain and m…