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Which nerve block keeps your leg stronger after knee surgery?

NCT ID NCT07524387

Symptom relief Sponsor: Social Medical Corporation Daiyukai Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two types of nerve blocks—femoral triangle block and adductor canal block—given during knee replacement surgery. The goal is to see which one better preserves early leg muscle function and helps patients move sooner. About 136 adults undergoing knee replacement will be randomly assigned to receive one of the blocks, along with standard pain management.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
levobupivacaine
What this could lead to
If successful, this study could help surgeons choose the best nerve block to preserve leg strength right after knee replacement surgery.
What could go wrong
This is a small, early-stage trial with 136 participants, so results may not apply to all patients. The difference between the two blocks may be small or not clinically meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 136 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adult patients (≥ 20 years of age) are scheduled to undergo primary unilateral TKA. 2. American Society of Anesthesiologists (ASA) physical status I-III. 3. Ability to ambulate independently prior to surgery. 4. Ability to understand the study procedures and provide written informed consent. 5. Planned perioperative anesthesia management including regional anesthesia as part of standard clinical care. 6. Ability to extend the knee below 30 degrees preoperatively (no knee extension contracture) Exclusion Criteria: 1. Known allergy or contraindication to local anesthetic agents used in this study. 2. Pre-existing neurological or neuromuscular disorders affect lower limb strength or motor control. 3. Severe cognitive impairment or psychiatric conditions interfere with study participation or assessment. 4. History of revision knee arthroplasty on the operative side. 5. Severe preoperative quadriceps weakness that precludes reliable baseline strength assessment. 6. Any condition deemed by the investigator to make participation inappropriate.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Total knee arthroplasty Total knee arthroplasty (postoperative pain) Total knee arthroplasty recovery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Anesthesiology, Daiyukai General Hospital

    RECRUITING

    Ichinomiya, Aichi-ken, 491-8511, Japan

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