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Can a single steroid dose transform knee replacement recovery?

NCT ID NCT05018091

Symptom relief Sponsor: Rush University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial compares three doses of dexamethasone (4 mg, 8 mg, and 16 mg) given during total knee replacement surgery to see which one best reduces pain, opioid use, and nausea after the operation. Adults having a primary knee replacement and staying at least one night in the hospital are eligible. The study measures opioid consumption and pain scores over the first 48 hours, along with nausea and blood sugar levels, to find the safest and most effective dose.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexamethasone, a corticosteroid given intravenously during surgery
What this could lead to
If successful, this could identify the optimal dexamethasone dose to improve recovery after knee replacement, reducing pain and opioid use.
What could go wrong
The trial is testing different doses, and higher doses may increase risks like blood sugar spikes. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

438 people

The number who actually took part.

Started

Oct 2021

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years * Primary total knee arthroplasty * Patients staying at least one night in the hospital after surgery Exclusion Criteria: * Same day discharge Age \< 18 years Revision or partial total knee arthroplasty Corticosteroid use within 3 months prior to surgery Inflammatory arthritis Current systemic fungal infection Renal or liver failure Prior adverse reaction to corticosteroid Primary TKA requiring hardware removal

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Total knee arthroplasty

Contacts and locations

Locations

  • Columbia University Irving Medical Center

    New York, New York, 10032, United States

  • Jefferson Philadelphia University and Thomas Jefferson University

    Philadelphia, Pennsylvania, 19107, United States

  • Mass General Brigham

    Somerville, Massachusetts, 02145, United States

  • Mayo Clinic Institutional Review

    Rochester, Minnesota, 55902, United States

  • NYU Langone Health

    New York, New York, 10016, United States

  • Rush University medical Center

    Chicago, Illinois, 60612, United States

  • Stanford University

    Redwood City, California, 94063, United States

  • University of California, San Francisco

    San Francisco, California, 94158, United States

  • University of Pennsylvania Perelman School of Medicine

    Philadelphia, Pennsylvania, 19104, United States

  • Washington University

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.