TOTAL KNEE ARTHROPLASTY
Clinical trials for TOTAL KNEE ARTHROPLASTY explained in plain language.
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New wound dressing may cut infection risk after joint revision surgery
Disease control CompletedThis study looked at whether a special vacuum dressing (negative pressure wound therapy) can reduce surgical site infections in high-risk patients undergoing revision of a hip or knee replacement. 104 patients were enrolled and followed after surgery. The main goal was to see how…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: NA • Sponsor: Molnlycke Health Care AB • Aim: Disease control
Last updated May 22, 2026 13:50 UTC
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Squeeze toy or sonnet? study tests fun ways to ease Post-Surgery pain
Symptom relief CompletedThis study looked at whether simple distractions like a virtual reality headset, a squishy squeeze toy, or listening to poetry can help control pain after total knee replacement surgery. 140 adults were split into four groups to try one of these methods or receive standard care. …
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: NA • Sponsor: Izmir Tinaztepe University • Aim: Symptom relief
Last updated May 26, 2026 02:56 UTC
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Phone Follow-Up boosts knee replacement recovery, study finds
Symptom relief CompletedThis study tested whether telehealth (phone or video) nursing support after knee replacement surgery helps patients recover function, take care of themselves, and do daily activities. 64 adults who had knee replacement took part. The intervention group got 14 days of telehealth e…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: NA • Sponsor: Sakarya Applied Sciences University • Aim: Symptom relief
Last updated May 26, 2026 02:55 UTC
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Knee replacement recovery boosted by simple exercise, study finds
Symptom relief CompletedThis study looked at whether doing quadriceps (thigh muscle) exercises helps people who have had a total knee replacement. 36 adults between 40 and 60 years old, who were 1 month to 1 year post-surgery, took part. The goal was to see if these exercises could improve knee movement…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated May 26, 2026 02:55 UTC
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Knee replacement pain relief: IV lidocaine may match nerve block
Symptom relief CompletedThis study tested whether giving lidocaine through an IV works as well as a numbing shot near the knee (nerve block) for pain after knee replacement. 120 adults having knee surgery were randomly assigned to one of the two methods. The main goal was to see how much opioid pain med…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: PHASE4 • Sponsor: Rhode Island Hospital • Aim: Symptom relief
Last updated May 26, 2026 02:53 UTC
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Could a common antidepressant ease knee surgery pain?
Symptom relief CompletedThis study looked at whether duloxetine, a medication usually used for depression, can help reduce pain and the need for strong painkillers after knee replacement surgery. 241 adults having knee replacement took part. The goal was to see if adding duloxetine to standard pain trea…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: PHASE4 • Sponsor: Rush University Medical Center • Aim: Symptom relief
Last updated May 26, 2026 02:46 UTC
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Can a Cannabis-Like drug cut opioid use after knee surgery?
Symptom relief CompletedThis study tested whether dronabinol, a drug similar to cannabis, can help reduce the need for opioid painkillers after knee replacement surgery. 114 adults were randomly assigned to receive either dronabinol or a placebo before and after surgery. Researchers measured opioid use,…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: PHASE4 • Sponsor: Hospital for Special Surgery, New York • Aim: Symptom relief
Last updated May 26, 2026 02:45 UTC
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New nerve block technique may offer better pain control after knee surgery
Symptom relief CompletedThis study tested two types of nerve blocks to control pain after total knee replacement. 62 patients received either a newer para-sartorial block or a standard femoral-sciatic block. Researchers measured how much extra pain medicine was needed and how well patients could move th…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: NA • Sponsor: Ain Shams University • Aim: Symptom relief
Last updated May 26, 2026 02:44 UTC
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New patch could replace opioids for knee surgery pain
Symptom relief CompletedThis study tested a device called NEUROCUPLE™, a patch worn for 30 days after knee replacement surgery, to see if it reduces pain and the need for opioid painkillers. 156 adults having knee replacement took part, with half receiving the active patch and half a placebo patch. The …
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: NA • Sponsor: nCap Medical • Aim: Symptom relief
Last updated May 26, 2026 02:44 UTC
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Tapping away pain: new study tests emotional freedom technique on knee surgery patients
Symptom relief CompletedThis study looked at whether Emotional Freedom Technique (EFT), a therapy that involves tapping on specific body points, can help reduce pain and anxiety after total knee replacement surgery. 80 adults having their first knee replacement were included. Researchers measured pain a…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: NA • Sponsor: Ataturk University • Aim: Symptom relief
Last updated May 22, 2026 14:03 UTC
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New heat treatment offers hope for stubborn knee pain after replacement
Symptom relief CompletedThis small pilot study tested a treatment called genicular nerve radiofrequency ablation (RFA) for people with long-term knee pain after a total knee replacement. The treatment uses heat to calm specific nerves around the knee. Five adults aged 30 to 90 who had at least one year …
Matched conditions: TOTAL KNEE ARTHROPLASTY
Sponsor: University of Utah • Aim: Symptom relief
Last updated May 22, 2026 13:54 UTC
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App-Assisted recovery boosts joint replacement rehab
Symptom relief CompletedThis study tested whether a smartphone app, used alongside standard recovery care, helps people recover better after hip or knee replacement surgery. 140 adults aged 18-80 who were scheduled for surgery took part. The app provided personalized rehab plans, progress tracking, and …
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: NA • Sponsor: The Affiliated Hospital Of Southwest Medical University • Aim: Symptom relief
Last updated May 22, 2026 13:52 UTC
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Which nerve block wins for knee replacement pain?
Symptom relief CompletedThis study tested three different nerve blocks to see which provides the best pain relief after total knee replacement. Sixty adults having knee surgery under general anesthesia received one of the blocks. The main goal was to measure how long it took before they needed extra pai…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: NA • Sponsor: Tanta University • Aim: Symptom relief
Last updated May 22, 2026 13:52 UTC
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Breathe away the fear: relaxation technique eases anxiety after knee surgery
Symptom relief CompletedThis study looked at whether a relaxation technique called Benson's relaxation exercise could help people who had total knee replacement surgery feel less anxious and less afraid of moving their new knee. 64 patients took part. The results showed that doing this simple relaxation…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: NA • Sponsor: Satı Danacı • Aim: Symptom relief
Last updated May 18, 2026 12:08 UTC
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Practice makes perfect: simulation eases fear before knee replacement
Symptom relief CompletedThis study tested whether a hands-on practice session before knee replacement surgery could help patients feel less afraid and worried. 48 adults scheduled for knee replacement were split into two groups: one received standard education, the other a simulation-based session. Rese…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: NA • Sponsor: Nermin Ocaktan • Aim: Symptom relief
Last updated May 14, 2026 12:03 UTC
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Less may be more: study tests best dose for knee surgery pain relief
Symptom relief CompletedThis study looked at 120 people having knee replacement surgery to see if using 10 mL or 20 mL of numbing medicine for a nerve block (popliteal plexus block) works better for pain. The goal was to reduce the need for strong painkillers (opioids) in the first 24 hours after surger…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: PHASE4 • Sponsor: Regionshospitalet Silkeborg • Aim: Symptom relief
Last updated May 13, 2026 16:02 UTC
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Knee replacement revision system shows promise in 118-Patient review
Knowledge-focused CompletedThis study looked at 118 people who had a second knee replacement surgery using the Medacta GMK Revision system with 3D metal cones. The goal was to see how well the knee worked and how safe the system was after at least one year. Researchers collected patient reports on pain, fu…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Sponsor: Medacta International SA • Aim: Knowledge-focused
Last updated May 26, 2026 02:56 UTC
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Spinal Anesthesia's hidden heart effect revealed in knee surgery study
Knowledge-focused CompletedThis study looked at 80 adults aged 45-85 having knee replacement surgery under spinal anesthesia. Researchers measured heart electrical activity (ECG) before and after the anesthesia to see if it changes. The goal was simply to observe and learn, not to treat or cure any conditi…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Sponsor: Sevim Şenol Karataş • Aim: Knowledge-focused
Last updated May 26, 2026 02:54 UTC
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Heart rate clues may forecast Post-Surgery pain
Knowledge-focused CompletedThis study looked at 110 knee replacement patients to see if heart rate variability (HRV) could predict a sudden, intense pain called rebound pain after nerve blocks wear off. Researchers measured HRV before and after surgery using a chest monitor. The goal is to help doctors per…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Sponsor: Konya City Hospital • Aim: Knowledge-focused
Last updated May 26, 2026 02:52 UTC
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Timing of drain removal after knee surgery may affect recovery
Knowledge-focused CompletedThis study looked at whether removing a surgical drain before or after the first physical therapy session affects recovery after total knee replacement. Researchers followed 207 adults with knee osteoarthritis who had knee replacement surgery. The goal was to see if drain timing …
Matched conditions: TOTAL KNEE ARTHROPLASTY
Sponsor: Ankara City Hospital Bilkent • Aim: Knowledge-focused
Last updated May 26, 2026 02:51 UTC
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Knee surgery anesthesia study reveals heart rhythm clues
Knowledge-focused CompletedThis study looked at 140 adults having knee replacement surgery to see if spinal or general anesthesia changes the heart's electrical signals differently. Researchers measured heart activity before and after surgery using a standard ECG. The goal was to understand how the choice …
Matched conditions: TOTAL KNEE ARTHROPLASTY
Sponsor: Elazıg Fethi Sekin Sehir Hastanesi • Aim: Knowledge-focused
Last updated May 26, 2026 02:46 UTC
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Knee replacement patients: beware of 'Rebound Pain' after nerve block wears off
Knowledge-focused CompletedThis study followed 294 knee replacement patients to see how often they experienced a sudden, severe pain when their nerve block wore off. Researchers found that many patients reported high pain levels within 12-24 hours after surgery. The goal was to better understand this 'rebo…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Sponsor: Konya City Hospital • Aim: Knowledge-focused
Last updated May 26, 2026 02:44 UTC
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Knee replacement recovery: when is it safe to go home?
Knowledge-focused CompletedThis study looked at 33 people who had knee replacement surgery to see if checking their recovery at 6 hours after surgery is as good as checking at 24 hours. The goal is to find the best time to safely send patients home. Researchers used a standard scoring system to measure how…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: NA • Sponsor: Thammasat University Hospital • Aim: Knowledge-focused
Last updated May 22, 2026 14:03 UTC
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Knee surgery drain debate: new study reveals blood loss findings
Knowledge-focused CompletedThis study looked at whether placing a drain after knee replacement surgery affects how much hemoglobin drops and whether a blood transfusion is needed. 102 adults having knee replacement took part, with half getting a drain and half not. Researchers measured hemoglobin before su…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Phase: NA • Sponsor: Shifa International Hospital • Aim: Knowledge-focused
Last updated May 20, 2026 11:55 UTC
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Which surgery best stops knee infection from coming back?
Knowledge-focused CompletedThis study looked at 145 people who had a knee replacement and later got an infection. Doctors compared four different surgeries to see which one best prevented the infection from returning or needing another surgery. The goal was to help surgeons choose the best treatment for ea…
Matched conditions: TOTAL KNEE ARTHROPLASTY
Sponsor: First Affiliated Hospital of Fujian Medical University • Aim: Knowledge-focused
Last updated May 20, 2026 11:54 UTC