TOTAL KNEE ARTHROPLASTY

This study tests a new drug, BT-114143, to see if it can reduce blood loss during knee replacement surgery better than the current standard treatment. About 270 adults having knee replacement will receive either a high or low dose of BT-114143 or tranexamic acid. The main goal is…

This study looks at whether whole-body vibration therapy can help women with low bone density recover better after total knee replacement. 48 women will be split into three groups: vibration only, vibration plus exercise, or standard rehab. Researchers will measure bone turnover,…

This study tests whether taking a supplement called GlyNAC (glycine and N-acetyl-cysteine) before and after knee replacement surgery can reduce oxidative stress and prevent chronic pain. About 148 adults aged 50+ with knee osteoarthritis will be followed for 12 months. The goal i…

This study tests if a continuous nerve catheter placed in the thigh provides better pain relief and reduces opioid use compared to a single nerve block after total knee replacement. About 64 adults will be randomly assigned to receive either the catheter or a sham catheter plus a…

This study tests three different nerve block techniques added to standard pain control for people having knee replacement surgery. The goal is to find which method best reduces pain while preserving leg strength for faster recovery. About 102 adults will participate, and their pa…

After total knee replacement, many patients experience lasting leg weakness. This study tests whether adding neuromuscular electrical stimulation (NMES) to standard physical therapy can improve strength and mobility. Researchers will enroll 3,250 patients across two large healthc…

This pilot study is testing a new wheeled mobility tool to see if it helps people move around more easily after total knee replacement surgery. About 19 adults who are already able to walk with at most a cane or crutch will use the device and have their mobility and pain tracked …

This study tests whether listening to binaural beats (special sound patterns) or your favorite music for 30 minutes after knee or hip replacement surgery can lower pain and anxiety. Fifty adults having these surgeries will be randomly assigned to one of the two listening options.…

This study tests whether a special navigation system (NextAR) helps surgeons place a new knee joint more naturally. About 100 people with severe knee arthritis will be randomly assigned to get surgery with or without this system. The goal is to see if patients feel so good they f…

This study tests whether freezing certain nerves (cryoablation) during total knee replacement can reduce pain and the need for opioid painkillers afterward. About 215 adults scheduled for knee replacement will be randomly assigned to receive either standard surgery or surgery plu…

This study compares two pain-blocking techniques for people having total knee replacement. Both methods target the back of the knee to reduce pain without affecting leg strength. The goal is to see which approach provides better pain relief, lowers the need for opioids, and helps…

This study tests whether wearing active noise-cancelling headphones with music or a movie can help patients stay calm and need less sedation during knee replacement surgery done under spinal anesthesia. About 200 adults having their first knee replacement will take part. The goal…

This study tests two different ways to numb the back of the knee after total knee replacement surgery. Both methods are combined with a standard front-of-thigh block. The goal is to see which approach provides better pain control, helps patients move sooner, and improves overall …

This study compares two types of nerve blocks (femoral triangle block vs. adductor canal block) to see which one helps people regain leg strength sooner after total knee replacement. About 136 adults having knee surgery will be randomly assigned to receive one of the blocks, plus…

This study tests three different doses of a long-lasting painkiller (liposomal bupivacaine) injected near the knee nerve to see which works best after total knee replacement. About 177 adults having robotic knee surgery will take part. The goal is to find the dose that reduces pa…

This study tests a new tool that helps physical therapists create personalized recovery plans for veterans after knee replacement surgery. Instead of a one-size-fits-all approach, the tool adjusts therapy based on each person's progress and goals. The goal is to improve how well …

This study tests whether wearing a knee brace for 72 hours after total knee replacement can reduce pain and help recovery. About 106 adults having knee replacement will either wear the brace or follow standard care. The goal is to see if this simple approach is worth testing in a…

This study looks at whether teaching patients about nutrition and following a specific fasting plan before knee replacement surgery can reduce thirst, nausea, and vomiting after the operation. About 72 adults having knee replacement will be split into two groups: one gets the spe…

This study tests whether a short course of oral methylprednisolone (a steroid) after knee replacement surgery can reduce pain, the need for opioids, and nausea. About 420 adults having their first knee replacement will be randomly assigned to receive either the steroid or a place…

This study compares two types of robotic-assisted total knee replacement surgery for people with knee osteoarthritis. One method uses cement to fix the new joint in place, while the other does not. The goal is to see which approach helps patients feel more like their knee is natu…

This study compares two types of nerve blocks to control pain after total knee replacement surgery. About 52 adults having knee replacement will receive either a combination of adductor canal and iPACK blocks or a suprainguinal fascia iliaca block. The goal is to see which method…

This study tests a new way to numb pain during knee replacement surgery. Doctors will inject a long-lasting anesthetic directly into the back and inner side of the knee joint. About 60 adults having knee replacement will be randomly assigned to one of three pain-blocking methods.…

This study looks at how a person's neighborhood resources affect their recovery after knee replacement surgery. Researchers will use a remote monitoring device to track physical progress and compare it to standard care. The goal is to see if remote monitoring can reduce the numbe…

This study tests three methods of giving the antibiotic vancomycin during total knee replacement: injection into the joint, into the bone, or through a vein. The goal is to see which method best reaches the tissues to prevent serious infections. About 30 adults having knee surger…

This study looks at how much fluid is needed to fully clean an infected knee replacement during a special surgery called DAIR. About 20 adults having knee revision surgery will take part. Doctors will use a blue dye to track contamination and take photos every 2 liters until the …

This study looks at whether special insoles that measure how you walk, along with other health information, can predict how much your knee will improve after replacement surgery. About 200 adults with knee osteoarthritis scheduled for surgery will participate. The goal is to help…