Knee surgery pain relief: which nerve block works best?
NCT ID NCT07092982
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two types of nerve blocks for pain after total knee replacement. One method uses a combination of adductor canal and iPACK blocks, the other uses a suprainguinal fascia iliaca block. The goal is to see which provides better pain control, reduces opioid use, and lowers stress on the body. Fifty-two adults having knee replacement will be randomly assigned to one of the two groups.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Bupivacaine (a numbing medicine)
- What this could lead to
- If one nerve block method proves better, it could lead to less pain and opioid use after knee replacement surgery.
- What could go wrong
- This is a small, early-phase study with only 52 patients. Results may not apply to everyone, and both methods are already in use, so no major breakthrough is expected.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 52 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2025
- Expected to finish
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Jul 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients undergoing total knee arthroplasty * Patients aged 18-75 * Patients with ASA I-II-III Exclusion Criteria: * Coagulation disorders * Allergy to local anesthetics * Liver and renal failure * Alcohol and drug addiction * Cognitive dysfunction that may prevent pain assessment * Systemic or needle insertion site infection * Analgesic use for more than 3 months * Patient refusal to participate in the study/refusal to consent * Presence of a hematoma, hernia, neoplasm, etc. in the area where the block will be performed * Pre-existing neurological deficit * Patients with contraindications to nerve block
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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SB Istanbul Education and Research Hospital
RECRUITINGIstanbul, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a single steroid dose transform knee replacement recovery?
- Can the right anesthesia get knee replacement patients moving faster?
- Can relaxation exercises boost recovery after knee replacement?