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Knee surgery pain relief: which nerve block works best?

NCT ID NCT07092982

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two types of nerve blocks for pain after total knee replacement. One method uses a combination of adductor canal and iPACK blocks, the other uses a suprainguinal fascia iliaca block. The goal is to see which provides better pain control, reduces opioid use, and lowers stress on the body. Fifty-two adults having knee replacement will be randomly assigned to one of the two groups.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Bupivacaine (a numbing medicine)
What this could lead to
If one nerve block method proves better, it could lead to less pain and opioid use after knee replacement surgery.
What could go wrong
This is a small, early-phase study with only 52 patients. Results may not apply to everyone, and both methods are already in use, so no major breakthrough is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 52 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing total knee arthroplasty * Patients aged 18-75 * Patients with ASA I-II-III Exclusion Criteria: * Coagulation disorders * Allergy to local anesthetics * Liver and renal failure * Alcohol and drug addiction * Cognitive dysfunction that may prevent pain assessment * Systemic or needle insertion site infection * Analgesic use for more than 3 months * Patient refusal to participate in the study/refusal to consent * Presence of a hematoma, hernia, neoplasm, etc. in the area where the block will be performed * Pre-existing neurological deficit * Patients with contraindications to nerve block

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • SB Istanbul Education and Research Hospital

    RECRUITING

    Istanbul, Turkey (Türkiye)

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